Cerebral white matter integrity during primary HIV infection

OBJECTIVE:Inflammation and infection within the central nervous system is initiated during primary HIV infection (PHI), but the association of these processes with the integrity of brain white matter during PHI is unknown. DESIGN:We used diffusion tensor imaging (DTI) in this prospective cross-secti...

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Veröffentlicht in:	AIDS (London) 2015-02, Vol.29 (4), p.433-442
Hauptverfasser:	Wright, Patrick W, Vaida, Florin F, Fernández, Ricardo J, Rutlin, Jerrel, Price, Richard W, Lee, Evelyn, Peterson, Julia, Fuchs, Dietmar, Shimony, Joshua S, Robertson, Kevin R, Walter, Rudolph, Meyerhoff, Dieter J, Spudich, Serena, Ances, Beau M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anti-HIV Agents - therapeutic use Biomarkers - blood Biomarkers - cerebrospinal fluid Blood-Brain Barrier CD4 Lymphocyte Count CD4-Positive T-Lymphocytes Central Nervous System - immunology Central Nervous System - physiopathology Central Nervous System - virology Corpus Callosum Cross-Sectional Studies Diffusion Tensor Imaging HIV Infections - blood HIV Infections - cerebrospinal fluid HIV Infections - immunology HIV Infections - physiopathology HIV-1 - immunology Human immunodeficiency virus 1 Humans Inflammation - immunology Inflammation - physiopathology Inflammation - virology Lentivirus Male Neuropsychological Tests Prospective Studies Retroviridae RNA, Viral Viral Load White Matter - immunology White Matter - physiopathology White Matter - virology
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Zusammenfassung:	OBJECTIVE:Inflammation and infection within the central nervous system is initiated during primary HIV infection (PHI), but the association of these processes with the integrity of brain white matter during PHI is unknown. DESIGN:We used diffusion tensor imaging (DTI) in this prospective cross-sectional neuroimaging study to determine the extent of white matter involvement in early HIV infection. METHODS:Antiretroviral-naive PHI (defined as
ISSN:	0269-9370 1473-5571
DOI:	10.1097/QAD.0000000000000560