Mycophenolic Acid and Its Derivatives as Potential Chemotherapeutic Agents Targeting Inosine Monophosphate Dehydrogenase in Trypanosoma congolense

This study aimed to evaluate the trypanocidal activity of mycophenolic acid (MPA) and its derivatives for Trypanosoma congolense The proliferation of T. congolense was completely inhibited by adding

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2016-07, Vol.60 (7), p.4391-4393
Hauptverfasser:	Suganuma, Keisuke, Sarwono, Albertus Eka Yudistira, Mitsuhashi, Shinya, Jąkalski, Marcin, Okada, Tadashi, Nthatisi, Molefe, Yamagishi, Junya, Ubukata, Makoto, Inoue, Noboru
Format:	Artikel
Sprache:	eng
Schlagworte:	Experimental Therapeutics IMP Dehydrogenase IMP Dehydrogenase - antagonists & inhibitors Mycophenolic Acid Mycophenolic Acid - chemistry Mycophenolic Acid - pharmacology Trypanocidal Agents Trypanocidal Agents - chemistry Trypanocidal Agents - pharmacology Trypanosoma congolense Trypanosoma congolense - drug effects
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Beschreibung
Zusammenfassung:	This study aimed to evaluate the trypanocidal activity of mycophenolic acid (MPA) and its derivatives for Trypanosoma congolense The proliferation of T. congolense was completely inhibited by adding
ISSN:	0066-4804 1098-6596
DOI:	10.1128/AAC.02816-15