Autophagy: a decisive process for stemness

Mature skeletal muscle is a stable tissue imposing low homeostatic demand on its stem cells, which remain in a quiescent state in their niche over time. We have shown that these long-lived resting stem cells attenuate proteotoxicity and avoid senescence through basal autophagy. This protective "...

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Veröffentlicht in:Oncotarget 2016-03, Vol.7 (11), p.12286-12288
Hauptverfasser: García-Prat, Laura, Martínez-Vicente, Marta, Muñoz-Cánoves, Pura
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Sprache:eng
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Zusammenfassung:Mature skeletal muscle is a stable tissue imposing low homeostatic demand on its stem cells, which remain in a quiescent state in their niche over time. We have shown that these long-lived resting stem cells attenuate proteotoxicity and avoid senescence through basal autophagy. This protective "clean-up" system is lost during aging, resulting in stem cell regenerative decline. Thus, autophagy is required for muscle stem cell homeostasis maintenance.
ISSN:1949-2553
1949-2553
DOI:10.18632/oncotarget.7766