Increased GSK-3β expression in DRG microglia in response to sciatic nerve crush

Neuronal loss and apoptosis often occur in peripheral nerve injury, which is associated with release of inflammatory molecules and activation of microglia/macrophages [1]. Excessive inflammatory response mediated by glial cells can exacerbate many neurological conditions and cause allodynia, hyperal...

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Veröffentlicht in:	Acta biochimica et biophysica Sinica 2016-06, Vol.48 (6), p.581-583
Hauptverfasser:	Tang, Wenjie, Li, Bing, Chen, Sheng, Lu, Ying, Han, Ning, Li, Xia, Li, Zengchun, Wei, Youzhen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium-Binding Proteins - metabolism Crush Injuries - enzymology Crush Injuries - metabolism Ganglia, Spinal - enzymology Ganglia, Spinal - metabolism Glial Fibrillary Acidic Protein - metabolism Glycogen Synthase Kinase 3 beta - metabolism Male Microfilament Proteins - metabolism Microglia - enzymology Microglia - metabolism New Phenomenon Rats Rats, Sprague-Dawley Sciatic Nerve - enzymology Sciatic Nerve - injuries Sciatic Nerve - metabolism 周围神经损伤坐骨神经小胶质细胞炎症反应神经系统疾病神经细胞神经胶质细胞背根神经节
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Zusammenfassung:	Neuronal loss and apoptosis often occur in peripheral nerve injury, which is associated with release of inflammatory molecules and activation of microglia/macrophages [1]. Excessive inflammatory response mediated by glial cells can exacerbate many neurological conditions and cause allodynia, hyperalgesia, neuropathic pain, and opioid tolerance [2].
ISSN:	1672-9145 1745-7270
DOI:	10.1093/abbs/gmw027