Structure, function and regulation of jade family PHD finger 1 (JADE1)

The family of JADE proteins includes three paralogues encoded by individual genes and designated PHF17 (JADE1), PHF16 (JADE2), and PHF15 (JADE3). All three JADE proteins bear in tandem two Plant Homeo-domains (PHD) which are zinc finger domains. This review focuses on one member of the JADE family, JADE1. Studies addressing the biochemical, cellular and biological role of JADE1 are discussed. Recent discoveries of JADE1 function in the regulation of the epithelial cell cycle with potential relevance to disease are presented. Unresolved questions and future directions are formulated. •PHD zinc finger proteins JADE1, JADE2, and JADE3 make up a small family of proteins.•JADE1 facilitates bulk histone H4 acetylation via interaction with an endogenous HAT.•JADE1S and JADE1L isoforms of JADE1 appear to play different cellular roles.•JADE1 proteins directly regulate cell cycle progression.•JADE1S is a negative regulator of cytokinesis and possibly the NoCut checkpoint.