Microbial pathogenesis and type III interferons

Microbial pathogenesis and type III interferons

Highlights • Human type III IFN polymorphisms can predict patient outcome. • Activated by both viral and bacterial pathogens. • Clinical data and mouse studies have shown a role for type III IFN in negatively contributing to infection. • Type III IFN is a potential target for host immunomodulation....

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Veröffentlicht in:Cytokine & growth factor reviews 2016-06, Vol.29, p.45-51
Hauptverfasser: Cohen, Taylor S, Parker, Dane
Format: Artikel
Sprache:eng
Schlagworte:
Advanced Basic Science
Animals
Bacteria
Bacterial Infections - immunology
Humans
Immunity, Innate
Influenza
Interferon
Interleukins - immunology
Microbial pathogenesis
Signal Transduction - immunology
Superinfection
Type III IFN
Virus Diseases - immunology
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Beschreibung
Zusammenfassung:Highlights • Human type III IFN polymorphisms can predict patient outcome. • Activated by both viral and bacterial pathogens. • Clinical data and mouse studies have shown a role for type III IFN in negatively contributing to infection. • Type III IFN is a potential target for host immunomodulation.
ISSN:1359-6101
1879-0305
DOI:10.1016/j.cytogfr.2016.02.005