Glial cell morphological and density changes through the lifespan of rhesus macaques

Highlights • Astrocytes become more complex during aging, peaking in adulthood. • Most complexity increase occurs close to astrocyte cell body. • Microglia become less complex, indicating possible activation. • Depression in eugeric aging could have a glial component.

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Bibliographische Detailangaben
Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2016-07, Vol.55, p.60-69
Hauptverfasser:	Robillard, Katelyn N, Lee, Kim M, Chiu, Kevin B, MacLean, Andrew G
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - physiology Allergy and Immunology Animals Astrocyte Astrocytes - cytology Female Glia Gray Matter - cytology Gray Matter - growth & development Humans Macaca mulatta Macaca mulatta - growth & development Male Microglia Microglia - cytology Psychiatry White Matter - cytology White Matter - growth & development
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Beschreibung
Zusammenfassung:	Highlights • Astrocytes become more complex during aging, peaking in adulthood. • Most complexity increase occurs close to astrocyte cell body. • Microglia become less complex, indicating possible activation. • Depression in eugeric aging could have a glial component.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2016.01.006