Bufalin enhances antitumor effect of paclitaxel on cervical tumorigenesis via inhibiting the integrin α2/β5/FAK signaling pathway

While Bufalin restrains primary tumorigenesis, the role of Bufalin in cervical cancer remains unclear. Here, we show that Bufalin can inhibit cervical cancer cell proliferation, block cell cycle in G2/M phase, induce cellular apoptosis and reduce cell metastasis through stimulation of p21(waf/cip1),...

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Veröffentlicht in:	Oncotarget 2016-02, Vol.7 (8), p.8896-8907
Hauptverfasser:	Liu, Fei, Tong, Duo, Li, Haoran, Liu, Mingming, Li, Jiajia, Wang, Ziliang, Cheng, Xi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Combined Chemotherapy Protocols - pharmacology Apoptosis - drug effects Blotting, Western Bufanolides - administration & dosage Cell Cycle - drug effects Cell Movement - drug effects Cell Proliferation - drug effects Cell Transformation, Neoplastic - drug effects Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology Drug Synergism Female Fluorescent Antibody Technique Focal Adhesion Kinase 1 - antagonists & inhibitors Focal Adhesion Kinase 1 - metabolism Humans Integrin alpha2 - chemistry Integrin alpha2 - metabolism Integrin beta Chains - chemistry Integrin beta Chains - metabolism Mice Mice, Inbred BALB C Mice, Nude Paclitaxel - administration & dosage Real-Time Polymerase Chain Reaction Research Paper Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Tumor Cells, Cultured Uterine Cervical Neoplasms - drug therapy Uterine Cervical Neoplasms - metabolism Uterine Cervical Neoplasms - pathology Xenograft Model Antitumor Assays
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Zusammenfassung:	While Bufalin restrains primary tumorigenesis, the role of Bufalin in cervical cancer remains unclear. Here, we show that Bufalin can inhibit cervical cancer cell proliferation, block cell cycle in G2/M phase, induce cellular apoptosis and reduce cell metastasis through stimulation of p21(waf/cip1), p27(cip/kip), Bax and E-cadherin, and suppression of cyclin A, cyclin B1, CDK2, Bcl-2, Bcl-xl, MMP9 and SNAIL1. Further study suggests that Bufalin has no apparent damage to human normal cervical cells at the low concentration (
ISSN:	1949-2553 1949-2553
DOI:	10.18632/oncotarget.6840