Increased expression of nuclear factor of activated T cells 1 drives IL-9–mediated allergic asthma

[...]the induced isoform D (variant 4) of NFATc1 was also found to be differentially expressed between asthmatic patients with a positive skin test result and nonasthmatic subjects with a negative skin test result (Table III). By contrast, this isoform is completely induced within a few hours after secondary stimulation.5 This is in line with our findings that NFATc1/A is upregulated in CD4+ T cells of asthmatic patients with a positive skin test result because these patients were already sensitized to an allergen. [...]we observed that NFATc1 isoform D (variant 4) was upregulated in asthmatic patients with a positive skin test result.