Characterization of cytoprotective and toxic properties of iron chelator SIH, prochelator BSIH and their degradation products
Highlights • Fe prochelator BSIH is nontoxic, stable and does not interfere with Fe homeostasis. • BSIH is activated by ROS to Fe chelator SIH that is prone to hydrolysis. • Salicylaldehyde is the main decomposition product of SIH and BSIH. • Salicylaldehyde retains chelating activity and significan...
Gespeichert in:
| Veröffentlicht in: | Toxicology (Amsterdam) 2016-03, Vol.350-352, p.15-24 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 24 |
|---|---|
| container_issue | |
| container_start_page | 15 |
| container_title | Toxicology (Amsterdam) |
| container_volume | 350-352 |
| creator | Jansová, Hana Bureš, Jan Macháček, Miloslav Hašková, Pavlína Jirkovská, Anna Roh, Jaroslav Wang, Qin Franz, Katherine J Kovaříková, Petra Šimůnek, Tomáš |
| description | Highlights • Fe prochelator BSIH is nontoxic, stable and does not interfere with Fe homeostasis. • BSIH is activated by ROS to Fe chelator SIH that is prone to hydrolysis. • Salicylaldehyde is the main decomposition product of SIH and BSIH. • Salicylaldehyde retains chelating activity and significant cytoprotective properties. • BSIH is promising compound with multiple active degradation products. |
| doi_str_mv | 10.1016/j.tox.2016.03.004 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4889448</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0300483X16300221</els_id><sourcerecordid>1825458652</sourcerecordid><originalsourceid>FETCH-LOGICAL-c572t-b99f8e673b321e631c168a90b34d694aa1ed8aa4465e232d9982e8c5fb6ae9e93</originalsourceid><addsrcrecordid>eNqNkk2LFDEQhoMo7jj6A7xIHz3Ybb46nSAsrIO6CwseVsFbSKdrdjL2dMYkPTiC_900vQ7qQfaUovJUVVLvi9BzgiuCiXi9rZL_XtEcVphVGPMHaEFko0pGZP0QLTDDuOSSfTlDT2LcYowp4-IxOqMN5qJRdIF-rjYmGJsguB8mOT8Ufl3YY_L74BPY5A5QmKEr8iBni5zcQ0gO4oS5kHG7gd4kH4qbq8tXE3BKvM2ZuXYDLhQd3AbTzTMy1o02xafo0dr0EZ7dnUv0-f27T6vL8vrjh6vVxXVp64amslVqLUE0rGWUgGDEEiGNwi3jnVDcGAKdNIZzUQNltFNKUpC2XrfCgALFluh87rsf2x10FoYUTK_3we1MOGpvnP77ZnAbfesPmkupeN7gEr28axD8txFi0jsXLfS9GcCPURNJa15LUdN7oFg2mElxD7RRpOFYNSyjZEZt8DEGWJ8eT7CezKC3OmukJzNozHQ2Q6558eevTxW_1c_AmxmAvPuDg6CjdTBY6FzI2uvOu_-2P_-n2vZucNb0X-EIcevHMGRRNdGRaqxvJjdOZiQiB5QS9gsRBdyv</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1791740973</pqid></control><display><type>article</type><title>Characterization of cytoprotective and toxic properties of iron chelator SIH, prochelator BSIH and their degradation products</title><source>Elsevier ScienceDirect Journals Complete - AutoHoldings</source><source>MEDLINE</source><creator>Jansová, Hana ; Bureš, Jan ; Macháček, Miloslav ; Hašková, Pavlína ; Jirkovská, Anna ; Roh, Jaroslav ; Wang, Qin ; Franz, Katherine J ; Kovaříková, Petra ; Šimůnek, Tomáš</creator><creatorcontrib>Jansová, Hana ; Bureš, Jan ; Macháček, Miloslav ; Hašková, Pavlína ; Jirkovská, Anna ; Roh, Jaroslav ; Wang, Qin ; Franz, Katherine J ; Kovaříková, Petra ; Šimůnek, Tomáš</creatorcontrib><description>Highlights • Fe prochelator BSIH is nontoxic, stable and does not interfere with Fe homeostasis. • BSIH is activated by ROS to Fe chelator SIH that is prone to hydrolysis. • Salicylaldehyde is the main decomposition product of SIH and BSIH. • Salicylaldehyde retains chelating activity and significant cytoprotective properties. • BSIH is promising compound with multiple active degradation products.</description><identifier>ISSN: 0300-483X</identifier><identifier>EISSN: 1879-3185</identifier><identifier>DOI: 10.1016/j.tox.2016.03.004</identifier><identifier>PMID: 27046792</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Aldehydes - pharmacology ; Aldehydes - toxicity ; Animals ; Biocompatibility ; Boronic Acids - pharmacology ; Boronic Acids - toxicity ; Boronyl salicylaldehyde isonicotinoyl hydrazone (BSIH) ; Cell Line ; Cell Survival - drug effects ; Cellular ; Chromatography, High Pressure Liquid ; Decomposition ; Emergency ; Half-Life ; Hydrazones - pharmacology ; Hydrazones - toxicity ; Hydrogen Peroxide - toxicity ; Iron ; Iron - metabolism ; Iron Chelating Agents - pharmacology ; Iron Chelating Agents - toxicity ; Iron chelation ; Isonicotinic Acids - pharmacology ; Isonicotinic Acids - toxicity ; Membrane Potential, Mitochondrial - drug effects ; Myoblasts, Cardiac - drug effects ; Myoblasts, Cardiac - metabolism ; Oxidative Stress - drug effects ; Prochelator ; Rats ; Reactive Oxygen Species - metabolism ; Salicylaldehyde ; Salicylaldehyde isonicotinoyl hydrazone (SIH) ; Salicylic acid ; Toxic ; Toxicity ; Toxicology</subject><ispartof>Toxicology (Amsterdam), 2016-03, Vol.350-352, p.15-24</ispartof><rights>2016 Elsevier Ireland Ltd</rights><rights>Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c572t-b99f8e673b321e631c168a90b34d694aa1ed8aa4465e232d9982e8c5fb6ae9e93</citedby><cites>FETCH-LOGICAL-c572t-b99f8e673b321e631c168a90b34d694aa1ed8aa4465e232d9982e8c5fb6ae9e93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.tox.2016.03.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27046792$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jansová, Hana</creatorcontrib><creatorcontrib>Bureš, Jan</creatorcontrib><creatorcontrib>Macháček, Miloslav</creatorcontrib><creatorcontrib>Hašková, Pavlína</creatorcontrib><creatorcontrib>Jirkovská, Anna</creatorcontrib><creatorcontrib>Roh, Jaroslav</creatorcontrib><creatorcontrib>Wang, Qin</creatorcontrib><creatorcontrib>Franz, Katherine J</creatorcontrib><creatorcontrib>Kovaříková, Petra</creatorcontrib><creatorcontrib>Šimůnek, Tomáš</creatorcontrib><title>Characterization of cytoprotective and toxic properties of iron chelator SIH, prochelator BSIH and their degradation products</title><title>Toxicology (Amsterdam)</title><addtitle>Toxicology</addtitle><description>Highlights • Fe prochelator BSIH is nontoxic, stable and does not interfere with Fe homeostasis. • BSIH is activated by ROS to Fe chelator SIH that is prone to hydrolysis. • Salicylaldehyde is the main decomposition product of SIH and BSIH. • Salicylaldehyde retains chelating activity and significant cytoprotective properties. • BSIH is promising compound with multiple active degradation products.</description><subject>Aldehydes - pharmacology</subject><subject>Aldehydes - toxicity</subject><subject>Animals</subject><subject>Biocompatibility</subject><subject>Boronic Acids - pharmacology</subject><subject>Boronic Acids - toxicity</subject><subject>Boronyl salicylaldehyde isonicotinoyl hydrazone (BSIH)</subject><subject>Cell Line</subject><subject>Cell Survival - drug effects</subject><subject>Cellular</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Decomposition</subject><subject>Emergency</subject><subject>Half-Life</subject><subject>Hydrazones - pharmacology</subject><subject>Hydrazones - toxicity</subject><subject>Hydrogen Peroxide - toxicity</subject><subject>Iron</subject><subject>Iron - metabolism</subject><subject>Iron Chelating Agents - pharmacology</subject><subject>Iron Chelating Agents - toxicity</subject><subject>Iron chelation</subject><subject>Isonicotinic Acids - pharmacology</subject><subject>Isonicotinic Acids - toxicity</subject><subject>Membrane Potential, Mitochondrial - drug effects</subject><subject>Myoblasts, Cardiac - drug effects</subject><subject>Myoblasts, Cardiac - metabolism</subject><subject>Oxidative Stress - drug effects</subject><subject>Prochelator</subject><subject>Rats</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Salicylaldehyde</subject><subject>Salicylaldehyde isonicotinoyl hydrazone (SIH)</subject><subject>Salicylic acid</subject><subject>Toxic</subject><subject>Toxicity</subject><subject>Toxicology</subject><issn>0300-483X</issn><issn>1879-3185</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk2LFDEQhoMo7jj6A7xIHz3Ybb46nSAsrIO6CwseVsFbSKdrdjL2dMYkPTiC_900vQ7qQfaUovJUVVLvi9BzgiuCiXi9rZL_XtEcVphVGPMHaEFko0pGZP0QLTDDuOSSfTlDT2LcYowp4-IxOqMN5qJRdIF-rjYmGJsguB8mOT8Ufl3YY_L74BPY5A5QmKEr8iBni5zcQ0gO4oS5kHG7gd4kH4qbq8tXE3BKvM2ZuXYDLhQd3AbTzTMy1o02xafo0dr0EZ7dnUv0-f27T6vL8vrjh6vVxXVp64amslVqLUE0rGWUgGDEEiGNwi3jnVDcGAKdNIZzUQNltFNKUpC2XrfCgALFluh87rsf2x10FoYUTK_3we1MOGpvnP77ZnAbfesPmkupeN7gEr28axD8txFi0jsXLfS9GcCPURNJa15LUdN7oFg2mElxD7RRpOFYNSyjZEZt8DEGWJ8eT7CezKC3OmukJzNozHQ2Q6558eevTxW_1c_AmxmAvPuDg6CjdTBY6FzI2uvOu_-2P_-n2vZucNb0X-EIcevHMGRRNdGRaqxvJjdOZiQiB5QS9gsRBdyv</recordid><startdate>20160328</startdate><enddate>20160328</enddate><creator>Jansová, Hana</creator><creator>Bureš, Jan</creator><creator>Macháček, Miloslav</creator><creator>Hašková, Pavlína</creator><creator>Jirkovská, Anna</creator><creator>Roh, Jaroslav</creator><creator>Wang, Qin</creator><creator>Franz, Katherine J</creator><creator>Kovaříková, Petra</creator><creator>Šimůnek, Tomáš</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7ST</scope><scope>7U7</scope><scope>C1K</scope><scope>SOI</scope><scope>8FD</scope><scope>FR3</scope><scope>KR7</scope><scope>5PM</scope></search><sort><creationdate>20160328</creationdate><title>Characterization of cytoprotective and toxic properties of iron chelator SIH, prochelator BSIH and their degradation products</title><author>Jansová, Hana ; Bureš, Jan ; Macháček, Miloslav ; Hašková, Pavlína ; Jirkovská, Anna ; Roh, Jaroslav ; Wang, Qin ; Franz, Katherine J ; Kovaříková, Petra ; Šimůnek, Tomáš</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c572t-b99f8e673b321e631c168a90b34d694aa1ed8aa4465e232d9982e8c5fb6ae9e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aldehydes - pharmacology</topic><topic>Aldehydes - toxicity</topic><topic>Animals</topic><topic>Biocompatibility</topic><topic>Boronic Acids - pharmacology</topic><topic>Boronic Acids - toxicity</topic><topic>Boronyl salicylaldehyde isonicotinoyl hydrazone (BSIH)</topic><topic>Cell Line</topic><topic>Cell Survival - drug effects</topic><topic>Cellular</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Decomposition</topic><topic>Emergency</topic><topic>Half-Life</topic><topic>Hydrazones - pharmacology</topic><topic>Hydrazones - toxicity</topic><topic>Hydrogen Peroxide - toxicity</topic><topic>Iron</topic><topic>Iron - metabolism</topic><topic>Iron Chelating Agents - pharmacology</topic><topic>Iron Chelating Agents - toxicity</topic><topic>Iron chelation</topic><topic>Isonicotinic Acids - pharmacology</topic><topic>Isonicotinic Acids - toxicity</topic><topic>Membrane Potential, Mitochondrial - drug effects</topic><topic>Myoblasts, Cardiac - drug effects</topic><topic>Myoblasts, Cardiac - metabolism</topic><topic>Oxidative Stress - drug effects</topic><topic>Prochelator</topic><topic>Rats</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Salicylaldehyde</topic><topic>Salicylaldehyde isonicotinoyl hydrazone (SIH)</topic><topic>Salicylic acid</topic><topic>Toxic</topic><topic>Toxicity</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jansová, Hana</creatorcontrib><creatorcontrib>Bureš, Jan</creatorcontrib><creatorcontrib>Macháček, Miloslav</creatorcontrib><creatorcontrib>Hašková, Pavlína</creatorcontrib><creatorcontrib>Jirkovská, Anna</creatorcontrib><creatorcontrib>Roh, Jaroslav</creatorcontrib><creatorcontrib>Wang, Qin</creatorcontrib><creatorcontrib>Franz, Katherine J</creatorcontrib><creatorcontrib>Kovaříková, Petra</creatorcontrib><creatorcontrib>Šimůnek, Tomáš</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Environment Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Civil Engineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Toxicology (Amsterdam)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jansová, Hana</au><au>Bureš, Jan</au><au>Macháček, Miloslav</au><au>Hašková, Pavlína</au><au>Jirkovská, Anna</au><au>Roh, Jaroslav</au><au>Wang, Qin</au><au>Franz, Katherine J</au><au>Kovaříková, Petra</au><au>Šimůnek, Tomáš</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of cytoprotective and toxic properties of iron chelator SIH, prochelator BSIH and their degradation products</atitle><jtitle>Toxicology (Amsterdam)</jtitle><addtitle>Toxicology</addtitle><date>2016-03-28</date><risdate>2016</risdate><volume>350-352</volume><spage>15</spage><epage>24</epage><pages>15-24</pages><issn>0300-483X</issn><eissn>1879-3185</eissn><abstract>Highlights • Fe prochelator BSIH is nontoxic, stable and does not interfere with Fe homeostasis. • BSIH is activated by ROS to Fe chelator SIH that is prone to hydrolysis. • Salicylaldehyde is the main decomposition product of SIH and BSIH. • Salicylaldehyde retains chelating activity and significant cytoprotective properties. • BSIH is promising compound with multiple active degradation products.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>27046792</pmid><doi>10.1016/j.tox.2016.03.004</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-483X |
| ispartof | Toxicology (Amsterdam), 2016-03, Vol.350-352, p.15-24 |
| issn | 0300-483X 1879-3185 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4889448 |
| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Aldehydes - pharmacology Aldehydes - toxicity Animals Biocompatibility Boronic Acids - pharmacology Boronic Acids - toxicity Boronyl salicylaldehyde isonicotinoyl hydrazone (BSIH) Cell Line Cell Survival - drug effects Cellular Chromatography, High Pressure Liquid Decomposition Emergency Half-Life Hydrazones - pharmacology Hydrazones - toxicity Hydrogen Peroxide - toxicity Iron Iron - metabolism Iron Chelating Agents - pharmacology Iron Chelating Agents - toxicity Iron chelation Isonicotinic Acids - pharmacology Isonicotinic Acids - toxicity Membrane Potential, Mitochondrial - drug effects Myoblasts, Cardiac - drug effects Myoblasts, Cardiac - metabolism Oxidative Stress - drug effects Prochelator Rats Reactive Oxygen Species - metabolism Salicylaldehyde Salicylaldehyde isonicotinoyl hydrazone (SIH) Salicylic acid Toxic Toxicity Toxicology |
| title | Characterization of cytoprotective and toxic properties of iron chelator SIH, prochelator BSIH and their degradation products |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T04%3A40%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Characterization%20of%20cytoprotective%20and%20toxic%20properties%20of%20iron%20chelator%20SIH,%20prochelator%20BSIH%20and%20their%20degradation%20products&rft.jtitle=Toxicology%20(Amsterdam)&rft.au=Jansov%C3%A1,%20Hana&rft.date=2016-03-28&rft.volume=350-352&rft.spage=15&rft.epage=24&rft.pages=15-24&rft.issn=0300-483X&rft.eissn=1879-3185&rft_id=info:doi/10.1016/j.tox.2016.03.004&rft_dat=%3Cproquest_pubme%3E1825458652%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1791740973&rft_id=info:pmid/27046792&rft_els_id=1_s2_0_S0300483X16300221&rfr_iscdi=true |