Characterization of cytoprotective and toxic properties of iron chelator SIH, prochelator BSIH and their degradation products

Highlights • Fe prochelator BSIH is nontoxic, stable and does not interfere with Fe homeostasis. • BSIH is activated by ROS to Fe chelator SIH that is prone to hydrolysis. • Salicylaldehyde is the main decomposition product of SIH and BSIH. • Salicylaldehyde retains chelating activity and significan...

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Veröffentlicht in:	Toxicology (Amsterdam) 2016-03, Vol.350-352, p.15-24
Hauptverfasser:	Jansová, Hana, Bureš, Jan, Macháček, Miloslav, Hašková, Pavlína, Jirkovská, Anna, Roh, Jaroslav, Wang, Qin, Franz, Katherine J, Kovaříková, Petra, Šimůnek, Tomáš
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes - pharmacology Aldehydes - toxicity Animals Biocompatibility Boronic Acids - pharmacology Boronic Acids - toxicity Boronyl salicylaldehyde isonicotinoyl hydrazone (BSIH) Cell Line Cell Survival - drug effects Cellular Chromatography, High Pressure Liquid Decomposition Emergency Half-Life Hydrazones - pharmacology Hydrazones - toxicity Hydrogen Peroxide - toxicity Iron Iron - metabolism Iron Chelating Agents - pharmacology Iron Chelating Agents - toxicity Iron chelation Isonicotinic Acids - pharmacology Isonicotinic Acids - toxicity Membrane Potential, Mitochondrial - drug effects Myoblasts, Cardiac - drug effects Myoblasts, Cardiac - metabolism Oxidative Stress - drug effects Prochelator Rats Reactive Oxygen Species - metabolism Salicylaldehyde Salicylaldehyde isonicotinoyl hydrazone (SIH) Salicylic acid Toxic Toxicity Toxicology
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Beschreibung
Zusammenfassung:	Highlights • Fe prochelator BSIH is nontoxic, stable and does not interfere with Fe homeostasis. • BSIH is activated by ROS to Fe chelator SIH that is prone to hydrolysis. • Salicylaldehyde is the main decomposition product of SIH and BSIH. • Salicylaldehyde retains chelating activity and significant cytoprotective properties. • BSIH is promising compound with multiple active degradation products.
ISSN:	0300-483X 1879-3185
DOI:	10.1016/j.tox.2016.03.004