Severe and Persistent Thyroid Dysfunction Associated with Tetracycline-Antibiotic Treatment in Youth

Thyroid dysfunction in adolescents treated with minocycline for acne has been previously described as transient effect and/or associated with autoimmune thyroiditis. We report nonimmune-mediated thyroid dysfunction associated with minocycline/doxycycline in 3 adolescents whose clinical courses sugge...

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Veröffentlicht in:	The Journal of pediatrics 2016-06, Vol.173, p.232-234
Hauptverfasser:	Pollock, Allison J., MD, Seibert, Tasa, MD, MPH, Allen, David B., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	acne vulgaris Acne Vulgaris - drug therapy Adolescent Anti-Bacterial Agents - adverse effects Diplopia - etiology doxycycline Fatigue - etiology Female Headache - etiology Humans hyperthyroidism Hyperthyroidism - chemically induced Hyperthyroidism - diagnosis hypothyroidism Male minocycline Minocycline - adverse effects Pediatrics Polydipsia - etiology tetracycline thyroid dysfunction thyroiditis Thyrotropin - blood Thyroxine - blood Weight Loss
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Beschreibung
Zusammenfassung:	Thyroid dysfunction in adolescents treated with minocycline for acne has been previously described as transient effect and/or associated with autoimmune thyroiditis. We report nonimmune-mediated thyroid dysfunction associated with minocycline/doxycycline in 3 adolescents whose clinical courses suggest an adverse effect that may be more common, serious, and persistent than realized previously.
ISSN:	0022-3476 1097-6833
DOI:	10.1016/j.jpeds.2016.03.034