Two-pore Channels Enter the Atomic Era: Structure of Plant TPC Revealed

Two-pore channels (TPCs) are intracellular Ca2+-permeable ion channels that are expressed on acidic Ca2+ stores. They are co-regulated by voltage and Ca2+ in plant vacuoles and by the second messenger NAADP in animal endo-lysosomes. Two new studies of plant TPC structures reveal essential features o...

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Veröffentlicht in:	Trends in biochemical sciences (Amsterdam. Regular ed.) 2016-06, Vol.41 (6), p.475-477
Hauptverfasser:	Patel, Sandip, Penny, Christopher J., Rahman, Taufiq
Format:	Artikel
Sprache:	eng
Schlagworte:	animals Arabidopsis - genetics Arabidopsis - metabolism Arabidopsis Proteins - chemistry Arabidopsis Proteins - genetics Arabidopsis Proteins - metabolism Binding Sites calcium Calcium - metabolism Calcium Channels - chemistry Calcium Channels - genetics Calcium Channels - metabolism Calcium Signaling Crystallography, X-Ray Endosomes - metabolism Gene Expression Ion Channel Gating ion channels Lysosomes - metabolism NADP - analogs & derivatives NADP - chemistry NADP - metabolism Protein Binding Protein Conformation, alpha-Helical Protein Interaction Domains and Motifs Spotlight vacuoles Vacuoles - chemistry Vacuoles - metabolism
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Zusammenfassung:	Two-pore channels (TPCs) are intracellular Ca2+-permeable ion channels that are expressed on acidic Ca2+ stores. They are co-regulated by voltage and Ca2+ in plant vacuoles and by the second messenger NAADP in animal endo-lysosomes. Two new studies of plant TPC structures reveal essential features of their architecture and provide mechanistic insight into their workings.
ISSN:	0968-0004 1362-4326
DOI:	10.1016/j.tibs.2016.04.007