A Systematic Review and Meta-Analysis of Cutaneous Manifestations in Late Versus Early-Onset Systemic Lupus Erythematosus

Objectives Although systemic lupus erythematosus (SLE) most commonly occurs in reproductive-age women, some are diagnosed after age 50. Recognizing that greater than one third of SLE criteria are cutaneous, we undertook a systematic review and meta-analysis to evaluate differences in cutaneous manif...

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Veröffentlicht in:	Seminars in arthritis and rheumatism 2016-06, Vol.45 (6), p.691-697
Hauptverfasser:	Medlin, Jennifer L., MD, Hansen, Karen E., MD MS, Fitz, Sara R., MD, Bartels, Christie M., MD MS
Format:	Artikel
Sprache:	eng
Schlagworte:	Age of Onset Alopecia Alopecia - etiology Alopecia - physiopathology Cutaneous Exanthema - etiology Exanthema - physiopathology Female Humans Late onset Late Onset Disorders - complications Late Onset Disorders - physiopathology Livedo Reticularis - etiology Livedo Reticularis - physiopathology Lupus Erythematosus, Systemic - complications Lupus Erythematosus, Systemic - physiopathology Malar rash Male Middle Aged Odds Ratio Photosensitivity Photosensitivity Disorders - etiology Photosensitivity Disorders - physiopathology Raynaud Raynaud Disease - etiology Raynaud Disease - physiopathology Rheumatology Sicca Skin Diseases - etiology Skin Diseases - physiopathology Systemic lupus erythematosus Vasculitis - etiology Vasculitis - physiopathology
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Zusammenfassung:	Objectives Although systemic lupus erythematosus (SLE) most commonly occurs in reproductive-age women, some are diagnosed after age 50. Recognizing that greater than one third of SLE criteria are cutaneous, we undertook a systematic review and meta-analysis to evaluate differences in cutaneous manifestations in early and late-onset SLE patients. Methods We searched the literature using PubMed, CINAHL, Web of Science and Cochrane Library. We excluded studies that did not include ACR SLE classification criteria, early-onset controls, that defined late-onset SLE as
ISSN:	0049-0172 1532-866X
DOI:	10.1016/j.semarthrit.2016.01.004