Subiculum–entorhinal cortex interactions during in vitro ictogenesis

Highlights • In intact horizontal brain slices, sudden onset ictal events often onset in the entorhinal cortex. • In intact horizontal brain slices, LVF onset ictal events predominantly initiated from the subiculum. • Severing connections between EC and subiculum abolished ictal discharge occurrence...

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Veröffentlicht in:	Seizure (London, England) England), 2015-09, Vol.31, p.33-40
Hauptverfasser:	Herrington, Rochelle, Lévesque, Maxime, Avoli, Massimo
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Aminopyridine Animals Anticonvulsants - pharmacology Entorhinal cortex Entorhinal Cortex - drug effects Entorhinal Cortex - physiopathology Epilepsy - drug therapy Epilepsy - physiopathology Hippocampus - drug effects Hippocampus - physiopathology Low-voltage fast onset Male Neurology Piperazines - pharmacology Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - metabolism Subiculum Sudden onset Tissue Culture Techniques
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Beschreibung
Zusammenfassung:	Highlights • In intact horizontal brain slices, sudden onset ictal events often onset in the entorhinal cortex. • In intact horizontal brain slices, LVF onset ictal events predominantly initiated from the subiculum. • Severing connections between EC and subiculum abolished ictal discharge occurrence in subiculum. • CPP blocked ictal events in the EC and fast trains of spikes in the isolated subiculum after cut. • CPP disrupted the rhythmicity of fast polyspike interictal discharges in the EC following cut.
ISSN:	1059-1311 1532-2688
DOI:	10.1016/j.seizure.2015.07.002