Levels of albuminuria and risk of developing macroalbuminuria in type 2 diabetes: historical cohort study
Although increased urinary albumin excretion may increase the risk of adverse renal outcomes in patients with diabetes, it remains unclear whether microalbuminuria is associated with a higher incidence of macroalbuminuria in the absence of non-diabetic kidney events that frequently develop during th...
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| Veröffentlicht in: | Scientific reports 2016-05, Vol.6 (1), p.26380-26380, Article 26380 |
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| creator | Chida, Shoma Fujita, Yoshikuni Ogawa, Akifumi Hayashi, Akinori Ichikawa, Raishi Kamata, Yuji Takeuchi, Akihiro Takano, Koji Shichiri, Masayoshi |
| description | Although increased urinary albumin excretion may increase the risk of adverse renal outcomes in patients with diabetes, it remains unclear whether microalbuminuria is associated with a higher incidence of macroalbuminuria in the absence of non-diabetic kidney events that frequently develop during the long-term course of type 2 diabetes. This historical cohort study included patients with type 2 diabetes, spot urine albumin:creatinine ratio (ACR) |
| doi_str_mv | 10.1038/srep26380 |
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This historical cohort study included patients with type 2 diabetes, spot urine albumin:creatinine ratio (ACR) <300 mg/gCr and normal serum creatinine concentrations treated between August 1988 and April 2015. Patients with any evidence suggesting non-diabetic kidney diseases at baseline were excluded. Over a median follow-up of 50 months, 70 of the 1760 included patients developed macroalbuminuria. Twenty-one of these patients were diagnosed with non-diabetic renal events. The five-year cumulative incidence of macroalbuminuria in patients with ACRs of 0–7.5 mg/gCr, 7.5–30 mg/gCr, 30–150 mg/gCr, and 150–300 mg/gCr were 0%, 0.53%, 3.5%, and 36.0%, respectively, with significant differences between each pair of ACR categories. In type 2 diabetes, higher urinary ACR, even within a level of normoalbuminuria, was associated with a greater incidence of macroalbuminuria when non-diabetic renal events were excluded. These results conflict with findings suggesting that microalbuminuria is a poor indicator for the progression of diabetic nephropathy.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep26380</identifier><identifier>PMID: 27210499</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/163/2743/137/138 ; 692/4022/1585/104 ; Aged ; Albumin ; Albuminuria - diagnosis ; Albuminuria - epidemiology ; Cohort analysis ; Cohort Studies ; Creatinine ; Creatinine - blood ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - urine ; Disease Progression ; Excretion ; Female ; Health risk assessment ; Humanities and Social Sciences ; Humans ; Incidence ; Kidney transplantation ; Kidneys ; Male ; Middle Aged ; multidisciplinary ; Nephropathy ; ROC Curve ; Science ; Science (multidisciplinary) ; Serum Albumin, Human - urine ; Urine</subject><ispartof>Scientific reports, 2016-05, Vol.6 (1), p.26380-26380, Article 26380</ispartof><rights>The Author(s) 2016</rights><rights>Copyright Nature Publishing Group May 2016</rights><rights>Copyright © 2016, Macmillan Publishers Limited 2016 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-7d1929a4b13a83cac49f4fa3f8de30e56d99bb5d72fc255b84b2fa98cc3ffcd13</citedby><cites>FETCH-LOGICAL-c504t-7d1929a4b13a83cac49f4fa3f8de30e56d99bb5d72fc255b84b2fa98cc3ffcd13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876475/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876475/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,27905,27906,41101,42170,51557,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27210499$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chida, Shoma</creatorcontrib><creatorcontrib>Fujita, Yoshikuni</creatorcontrib><creatorcontrib>Ogawa, Akifumi</creatorcontrib><creatorcontrib>Hayashi, Akinori</creatorcontrib><creatorcontrib>Ichikawa, Raishi</creatorcontrib><creatorcontrib>Kamata, Yuji</creatorcontrib><creatorcontrib>Takeuchi, Akihiro</creatorcontrib><creatorcontrib>Takano, Koji</creatorcontrib><creatorcontrib>Shichiri, Masayoshi</creatorcontrib><title>Levels of albuminuria and risk of developing macroalbuminuria in type 2 diabetes: historical cohort study</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Although increased urinary albumin excretion may increase the risk of adverse renal outcomes in patients with diabetes, it remains unclear whether microalbuminuria is associated with a higher incidence of macroalbuminuria in the absence of non-diabetic kidney events that frequently develop during the long-term course of type 2 diabetes. This historical cohort study included patients with type 2 diabetes, spot urine albumin:creatinine ratio (ACR) <300 mg/gCr and normal serum creatinine concentrations treated between August 1988 and April 2015. Patients with any evidence suggesting non-diabetic kidney diseases at baseline were excluded. Over a median follow-up of 50 months, 70 of the 1760 included patients developed macroalbuminuria. Twenty-one of these patients were diagnosed with non-diabetic renal events. The five-year cumulative incidence of macroalbuminuria in patients with ACRs of 0–7.5 mg/gCr, 7.5–30 mg/gCr, 30–150 mg/gCr, and 150–300 mg/gCr were 0%, 0.53%, 3.5%, and 36.0%, respectively, with significant differences between each pair of ACR categories. In type 2 diabetes, higher urinary ACR, even within a level of normoalbuminuria, was associated with a greater incidence of macroalbuminuria when non-diabetic renal events were excluded. These results conflict with findings suggesting that microalbuminuria is a poor indicator for the progression of diabetic nephropathy.</description><subject>692/163/2743/137/138</subject><subject>692/4022/1585/104</subject><subject>Aged</subject><subject>Albumin</subject><subject>Albuminuria - diagnosis</subject><subject>Albuminuria - epidemiology</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Creatinine</subject><subject>Creatinine - blood</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - urine</subject><subject>Disease Progression</subject><subject>Excretion</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Incidence</subject><subject>Kidney transplantation</subject><subject>Kidneys</subject><subject>Male</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Nephropathy</subject><subject>ROC Curve</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Serum Albumin, Human - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chida, Shoma</au><au>Fujita, Yoshikuni</au><au>Ogawa, Akifumi</au><au>Hayashi, Akinori</au><au>Ichikawa, Raishi</au><au>Kamata, Yuji</au><au>Takeuchi, Akihiro</au><au>Takano, Koji</au><au>Shichiri, Masayoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Levels of albuminuria and risk of developing macroalbuminuria in type 2 diabetes: historical cohort study</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2016-05-23</date><risdate>2016</risdate><volume>6</volume><issue>1</issue><spage>26380</spage><epage>26380</epage><pages>26380-26380</pages><artnum>26380</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Although increased urinary albumin excretion may increase the risk of adverse renal outcomes in patients with diabetes, it remains unclear whether microalbuminuria is associated with a higher incidence of macroalbuminuria in the absence of non-diabetic kidney events that frequently develop during the long-term course of type 2 diabetes. This historical cohort study included patients with type 2 diabetes, spot urine albumin:creatinine ratio (ACR) <300 mg/gCr and normal serum creatinine concentrations treated between August 1988 and April 2015. Patients with any evidence suggesting non-diabetic kidney diseases at baseline were excluded. Over a median follow-up of 50 months, 70 of the 1760 included patients developed macroalbuminuria. Twenty-one of these patients were diagnosed with non-diabetic renal events. The five-year cumulative incidence of macroalbuminuria in patients with ACRs of 0–7.5 mg/gCr, 7.5–30 mg/gCr, 30–150 mg/gCr, and 150–300 mg/gCr were 0%, 0.53%, 3.5%, and 36.0%, respectively, with significant differences between each pair of ACR categories. In type 2 diabetes, higher urinary ACR, even within a level of normoalbuminuria, was associated with a greater incidence of macroalbuminuria when non-diabetic renal events were excluded. These results conflict with findings suggesting that microalbuminuria is a poor indicator for the progression of diabetic nephropathy.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>27210499</pmid><doi>10.1038/srep26380</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 692/163/2743/137/138 692/4022/1585/104 Aged Albumin Albuminuria - diagnosis Albuminuria - epidemiology Cohort analysis Cohort Studies Creatinine Creatinine - blood Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - urine Disease Progression Excretion Female Health risk assessment Humanities and Social Sciences Humans Incidence Kidney transplantation Kidneys Male Middle Aged multidisciplinary Nephropathy ROC Curve Science Science (multidisciplinary) Serum Albumin, Human - urine Urine |
| title | Levels of albuminuria and risk of developing macroalbuminuria in type 2 diabetes: historical cohort study |
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