Different prognostic value of circulating and disseminated tumor cells in primary breast cancer: Influence of bisphosphonate intake?

Disseminated tumor cells (DTCs) in the bone marrow (BM) and circulating tumor cells (CTCs) in blood of breast cancer patients (pts) are known to correlate with worse outcome. Here we demonstrate a different prognostic value of DTCs and CTCs and explain these findings by early clodronate intake. CTCs...

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Veröffentlicht in:	Scientific reports 2016-05, Vol.6 (1), p.26355-26355, Article 26355
Hauptverfasser:	Kasimir-Bauer, Sabine, Reiter, Katharina, Aktas, Bahriye, Bittner, Ann-Kathrin, Weber, Stephan, Keller, Thomas, Kimmig, Rainer, Hoffmann, Oliver
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 13/100 38 631/67/1347 692/4028/67/1347 Adult Aged Aged, 80 and over Bisphosphonates Bone cancer Bone Density Conservation Agents - administration & dosage Bone Density Conservation Agents - pharmacology Bone marrow Bone Marrow - drug effects Bone Marrow - pathology Breast cancer Breast Neoplasms - pathology Clodronic acid Clodronic Acid - administration & dosage Clodronic Acid - pharmacology Cytokeratin Female Germany Humanities and Social Sciences Humans Immunocytochemistry Metastases Metastasis Middle Aged multidisciplinary Neoplastic Cells, Circulating - drug effects Neoplastic Cells, Circulating - pathology Post-menopause Prognosis Prospective Studies Radiation therapy Science Survival Analysis Tumor cells Tumors
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Zusammenfassung:	Disseminated tumor cells (DTCs) in the bone marrow (BM) and circulating tumor cells (CTCs) in blood of breast cancer patients (pts) are known to correlate with worse outcome. Here we demonstrate a different prognostic value of DTCs and CTCs and explain these findings by early clodronate intake. CTCs (n = 376 pts) were determined using the AdnaTest BreastCancer (Qiagen Hannover GmbH, Germany) and DTCs (n = 525 pts) were analyzed by immunocytochemistry using the pan-cytokeratin antibody A45-B/B3. Clodronate intake was recommended in case of DTC-positivity. CTCs were detected in 22% and DTCs in 40% of the pts, respectively. DTCs were significantly associated with nodal status (p = 0.03), grading (p = 0.01), lymphangiosis (p = 0.03), PR status (p = 0.02) and clodronate intake (p
ISSN:	2045-2322 2045-2322
DOI:	10.1038/srep26355