Genetic loci associated with ideal cardiovascular health: A meta-analysis of genome-wide association studies

Background Multiple genetic loci are associated with clinical cardiovascular (CV) disease and individual CV risk factors. Individuals with ideal levels of all major CV risk factors have very low risk for CV disease morbidity or mortality. Ideal levels of risk factors can be attained by lifestyle mod...

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Veröffentlicht in:	The American heart journal 2016-05, Vol.175, p.112-120
Hauptverfasser:	Allen, Norrina B., PhD, Lloyd-Jones, Donald, MD, ScM, Hwang, Shih-Jen, PhD, Rasmussen-Torvik, Laura, PhD, Fornage, Myriam, PhD, Morrison, Alanna C., PhD, Baldridge, Abigail S., MSEB, Boerwinkle, Eric, PhD, Levy, Daniel, MD, Cupples, L. Adrienne, PhD, Fox, Caroline S., MD, MPH, Thanassoulis, George, MD MSc, Dufresne, Line, MSc, Daviglus, Martha, MD, PhD, Johnson, Andrew D., PhD, Reis, Jared, PhD, Rotter, Jerome, MD, Palmas, Walter, MD, Allison, Mathew, MD, MPH, Pankow, James S., PhD, MPH, O'Donnell, Christopher J., MD, MPH
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Apolipoprotein C-I - genetics Atherosclerosis Blood pressure Body mass index Cardiovascular Cardiovascular Diseases - genetics Cholesterol Coronary vessels Diabetes Fasting Gene Expression Profiling - methods Genealogy Genetic Loci Genome-Wide Association Study Genomes Heart Humans Meta-analysis Metabolism Middle age Mortality Population Protective Factors Risk factors Software Studies Young adults
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Zusammenfassung:	Background Multiple genetic loci are associated with clinical cardiovascular (CV) disease and individual CV risk factors. Individuals with ideal levels of all major CV risk factors have very low risk for CV disease morbidity or mortality. Ideal levels of risk factors can be attained by lifestyle modifications; however, little is known about gene variants associated with ideal CV health. Our objective was to carry out a genome-wide association study on the trait. Methods and Results We examined 2 dichotomous phenotypes of ideal CV health—clinical (untreated cholesterol
ISSN:	0002-8703 1097-6744
DOI:	10.1016/j.ahj.2015.12.022