GABAA Circuit Level Mechanisms are Associated with Ether-induced Unconsciousness

GABAA Circuit Level Mechanisms are Associated with Ether-induced Unconsciousness

Highlights • Large amplitude slow oscillations, frontally coherent theta oscillations and frontally coherent alpha oscillations occur with the administration of modern day derivatives of ether. • Reduction of GABAergic inhibitory post-synaptic potentials with ketamine resulted in beta/gamma (13-40 H...

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Veröffentlicht in:Clinical neurophysiology 2016-02, Vol.127 (6), p.2472-2481
Hauptverfasser: Akeju, Oluwaseun, Hamilos, Allison E, Song, Andrew H, Pavone, Kara J, Purdon, Patrick L, Brown, Emery N
Format: Artikel
Sprache:eng
Schlagworte:
Neurology
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Zusammenfassung:Highlights • Large amplitude slow oscillations, frontally coherent theta oscillations and frontally coherent alpha oscillations occur with the administration of modern day derivatives of ether. • Reduction of GABAergic inhibitory post-synaptic potentials with ketamine resulted in beta/gamma (13-40 Hz) oscillations and significantly reduced MDDE-induced slow, theta and alpha oscillation power. • GABAA circuit-level mechanisms are associated with MDDE-induced unconsciousness.
ISSN:1388-2457
1872-8952
DOI:10.1016/j.clinph.2016.02.012