Identification of three ookinete-specific genes and evaluation of their transmission-blocking potentials in Plasmodium berghei

Highlights • We mined PlasmoDB and selected three ookinete-specific genes in Plasmodium. • We confirmed their expression and localization on P. berghei ookinetes. • Antisera against these recombinant proteins had transmission blocking activity.

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Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2016-05, Vol.34 (23), p.2570-2578
Hauptverfasser:	Zheng, Wenqi, Kou, Xu, Du, Yunting, Liu, Fei, Yu, Chunyun, Tsuboi, Takafumi, Fan, Qi, Luo, Enjie, Cao, Yaming, Cui, Liwang
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antibodies, Protozoan - blood Antigens Antigens, Protozoan - genetics Antigens, Protozoan - immunology antiserum Aquatic insects bacteria bioinformatics Candidates Computational Biology Culicidae Disease transmission Drug resistance Female Genes Genes, Protozoan humans Immune Sera - immunology Immunization Immunoglobulins Malaria Malaria - prevention & control Malaria - transmission Malaria Vaccines - immunology Membrane Proteins - genetics Membrane Proteins - immunology Mice Mice, Inbred BALB C Mosquitoes oocysts ookinetes Parasites Plasmodium berghei Plasmodium berghei - genetics Protein expression Protein folding protein synthesis Proteins recombinant proteins Recombinant Proteins - immunology Sexual stage Transmission-blocking vaccine Tropical diseases vaccines Vector-borne diseases
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Beschreibung
Zusammenfassung:	Highlights • We mined PlasmoDB and selected three ookinete-specific genes in Plasmodium. • We confirmed their expression and localization on P. berghei ookinetes. • Antisera against these recombinant proteins had transmission blocking activity.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2016.04.011