Dynamic nuclear polarization of biocompatible 13C-enriched carbonates for in vivo pH imaging

A hyperpolarization technique using carbonate precursors of biocompatible molecules was found to yield high concentrations of hyperpolarized 13 C bicarbonate in solution. This approach enabled large signal gains for low-toxicity hyperpolarized 13 C pH imaging in a phantom and in vivo in a murine mod...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2016-02, Vol.52 (14), p.3030-3033
Hauptverfasser: Korenchan, D. E., Flavell, R. R., Baligand, C., Sriram, R., Neumann, K., Sukumar, S., VanBrocklin, H., Vigneron, D. B., Wilson, D. M., Kurhanewicz, J.
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container_end_page 3033
container_issue 14
container_start_page 3030
container_title Chemical communications (Cambridge, England)
container_volume 52
creator Korenchan, D. E.
Flavell, R. R.
Baligand, C.
Sriram, R.
Neumann, K.
Sukumar, S.
VanBrocklin, H.
Vigneron, D. B.
Wilson, D. M.
Kurhanewicz, J.
description A hyperpolarization technique using carbonate precursors of biocompatible molecules was found to yield high concentrations of hyperpolarized 13 C bicarbonate in solution. This approach enabled large signal gains for low-toxicity hyperpolarized 13 C pH imaging in a phantom and in vivo in a murine model of prostate cancer.
doi_str_mv 10.1039/c5cc09724j
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title Dynamic nuclear polarization of biocompatible 13C-enriched carbonates for in vivo pH imaging
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