Dynamic nuclear polarization of biocompatible 13C-enriched carbonates for in vivo pH imaging
A hyperpolarization technique using carbonate precursors of biocompatible molecules was found to yield high concentrations of hyperpolarized 13 C bicarbonate in solution. This approach enabled large signal gains for low-toxicity hyperpolarized 13 C pH imaging in a phantom and in vivo in a murine mod...
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Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2016-02, Vol.52 (14), p.3030-3033 |
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container_title | Chemical communications (Cambridge, England) |
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creator | Korenchan, D. E. Flavell, R. R. Baligand, C. Sriram, R. Neumann, K. Sukumar, S. VanBrocklin, H. Vigneron, D. B. Wilson, D. M. Kurhanewicz, J. |
description | A hyperpolarization technique using carbonate precursors of biocompatible molecules was found to yield high concentrations of hyperpolarized
13
C bicarbonate in solution. This approach enabled large signal gains for low-toxicity hyperpolarized
13
C pH imaging in a phantom and
in vivo
in a murine model of prostate cancer. |
doi_str_mv | 10.1039/c5cc09724j |
format | Article |
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13
C bicarbonate in solution. This approach enabled large signal gains for low-toxicity hyperpolarized
13
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in vivo
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13
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13
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13
C bicarbonate in solution. This approach enabled large signal gains for low-toxicity hyperpolarized
13
C pH imaging in a phantom and
in vivo
in a murine model of prostate cancer.</abstract><pmid>26792559</pmid><doi>10.1039/c5cc09724j</doi></addata></record> |
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source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
title | Dynamic nuclear polarization of biocompatible 13C-enriched carbonates for in vivo pH imaging |
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