Dynamic nuclear polarization of biocompatible 13C-enriched carbonates for in vivo pH imaging

Dynamic nuclear polarization of biocompatible 13C-enriched carbonates for in vivo pH imaging

A hyperpolarization technique using carbonate precursors of biocompatible molecules was found to yield high concentrations of hyperpolarized 13 C bicarbonate in solution. This approach enabled large signal gains for low-toxicity hyperpolarized 13 C pH imaging in a phantom and in vivo in a murine mod...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2016-02, Vol.52 (14), p.3030-3033
Hauptverfasser: Korenchan, D. E., Flavell, R. R., Baligand, C., Sriram, R., Neumann, K., Sukumar, S., VanBrocklin, H., Vigneron, D. B., Wilson, D. M., Kurhanewicz, J.
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Sprache:eng
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Zusammenfassung:A hyperpolarization technique using carbonate precursors of biocompatible molecules was found to yield high concentrations of hyperpolarized 13 C bicarbonate in solution. This approach enabled large signal gains for low-toxicity hyperpolarized 13 C pH imaging in a phantom and in vivo in a murine model of prostate cancer.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc09724j