Optimising selective excitation pulses to maximise saturation transfer difference NMR spectroscopy

Optimising selective excitation pulses to maximise saturation transfer difference NMR spectroscopy

A simple method is presented that optimizes the STD NMR Gaussian pulse to deliver significant increases in STD amplification factors with minimal perturbation of the ligand. This approach is practically demonstrated using the wheat-germ agglutinin/N-acetyl-D-glucosamine protein-ligand system.

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Veröffentlicht in:RSC advances 2014, Vol.4 (14), p.7347-7351
Hauptverfasser: Ley, Nathan B, Rowe, Michelle L, Williamson, Richard A, Howard, Mark J
Format: Artikel
Sprache:eng
Schlagworte:
Amplification
Excitation
Gaussian
Ligands
NMR spectroscopy
Optimization
Perturbation
Saturation
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Beschreibung
Zusammenfassung:A simple method is presented that optimizes the STD NMR Gaussian pulse to deliver significant increases in STD amplification factors with minimal perturbation of the ligand. This approach is practically demonstrated using the wheat-germ agglutinin/N-acetyl-D-glucosamine protein-ligand system.
ISSN:2046-2069
2046-2069
DOI:10.1039/c3ra46246c