Novel patient-derived xenograft mouse model for pancreatic acinar cell carcinoma demonstrates single agent activity of oxaliplatin

Pancreatic acinar cell carcinoma (PACC) is a rare malignancy, accounting for

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of translational medicine 2016-05, Vol.14 (1), p.129, Article 129
Hauptverfasser:	Hall, Jason C, Marlow, Laura A, Mathias, Adam C, Dawson, Louis K, Durham, William F, Meshaw, Kenneth A, Mullin, Robert J, Synnott, Aidan J, Small, Daniel L, Krishna, Murli, von Hoff, Daniel, Schüler, Julia, Hart, Steven N, Couch, Fergus J, Colon-Otero, Gerardo, Copland, John A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects BRCA2 Protein - genetics Carcinoma, Acinar Cell - blood Carcinoma, Acinar Cell - blood supply Carcinoma, Acinar Cell - drug therapy Carcinoma, Acinar Cell - pathology Care and treatment Cell Proliferation - drug effects Cell Shape - drug effects Development and progression Endpoint Determination Female Fluorescent Antibody Technique Humans Lipase - blood Mice, Nude Mutation - genetics Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - pathology Organoplatinum Compounds - adverse effects Organoplatinum Compounds - pharmacology Organoplatinum Compounds - therapeutic use Oxaliplatin Pancreatic cancer Pancreatic Neoplasms Pancreatic Neoplasms - blood Pancreatic Neoplasms - blood supply Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - pathology Xenograft Model Antitumor Assays
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Beschreibung
Zusammenfassung:	Pancreatic acinar cell carcinoma (PACC) is a rare malignancy, accounting for
ISSN:	1479-5876 1479-5876
DOI:	10.1186/s12967-016-0875-z