IL-4 Gene Polymorphism May Contribute to an Increased Risk of Atopic Dermatitis in Children

IL-4 Gene Polymorphism May Contribute to an Increased Risk of Atopic Dermatitis in Children

This study aimed to elucidate the associations between interleukin-4 (IL-4) single nucleotide polymorphisms (SNPs), 590C/T and 589C/T, serum IL-4 levels, and atopic dermatitis (AD) in children. Methods. A total of 82 children with AD were randomly selected as the case group and divided into mild gro...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Disease markers 2016-01, Vol.2016 (2016), p.1-6
Hauptverfasser: Meng, Jin, Wan, Yu-Jie, Cao, Xiu-Li, Shang, Hong, Guo, Lu-Hong
Format: Artikel
Sprache:eng
Schlagworte:
Advertising executives
Atopic dermatitis
B cells
Child
Child, Preschool
Children
Dermatitis, Atopic - genetics
Dermatitis, Atopic - metabolism
Female
Gene Frequency
Genes
Genetic aspects
Genetic Predisposition to Disease
Genotype
Health aspects
Humans
Infant
Interleukin-4 - blood
Interleukin-4 - genetics
Interleukins
Male
Polymorphism, Single Nucleotide
Single nucleotide polymorphisms
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:This study aimed to elucidate the associations between interleukin-4 (IL-4) single nucleotide polymorphisms (SNPs), 590C/T and 589C/T, serum IL-4 levels, and atopic dermatitis (AD) in children. Methods. A total of 82 children with AD were randomly selected as the case group and divided into mild group (15 cases), moderate group (46 cases), and severe group (21 cases). Additionally, 100 healthy children were selected as the control group. Genotype frequencies of IL-4 SNPs were detected by PCR-RFLP. Serum IL-4 levels were measured by ELISA. Results. Significant differences were shown in genotype distributions and allele frequencies of 589C/T and allele frequencies of 590C/T (all P
ISSN:0278-0240
1875-8630
DOI:10.1155/2016/1021942