Degenerative Liver Disease in Young Beagles with Hereditary Cobalamin Malabsorption Because of a Mutation in the Cubilin Gene

A frameshift mutation in the cubilin gene (CUBN) in Border Collies with Imerslund-Gräsbeck syndrome (selective cobalamin malabsorption). A frameshift mutation in the cubilin gene (CUBN) in Beagles with Imerslund-Gr\xE4sbeck syndrome (selective cobalamin malabsorption). Ji C, Deng Q, Kaplowitz N. Rol...

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Veröffentlicht in:	Journal of veterinary internal medicine 2014-03, Vol.28 (2), p.666-671
Hauptverfasser:	Kook, P.H., Drögemüller, M., Leeb, T., Howard, J., Ruetten, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ascites Case Report Case Reports Cobalt Dog Diseases - genetics Dog Diseases - pathology Dogs Female Hepatopathy Homocysteine Liver - pathology Liver diseases Liver Diseases - etiology Liver Diseases - genetics Liver Diseases - pathology Liver Diseases - veterinary Malabsorption Syndromes - complications Malabsorption Syndromes - genetics Malabsorption Syndromes - pathology Malabsorption Syndromes - veterinary Male Mutation Mutation - genetics Neutropenia Oxidative stress Receptors, Cell Surface - genetics Vitamin B 12 - metabolism Vitamin B12 Vitamin deficiency
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Zusammenfassung:	A frameshift mutation in the cubilin gene (CUBN) in Border Collies with Imerslund-Gräsbeck syndrome (selective cobalamin malabsorption). A frameshift mutation in the cubilin gene (CUBN) in Beagles with Imerslund-Gr\xE4sbeck syndrome (selective cobalamin malabsorption). Ji C, Deng Q, Kaplowitz N. Role of TNF-alpha in ethanol-induced hyperhomocysteinemia and murine alcoholic liver injury. Cobalt-vitamin B12 deficiency causes lipid accumulation, lipid peroxidation and decreased alpha-tocopherol concentrations in the liver of sheep.
ISSN:	0891-6640 1939-1676
DOI:	10.1111/jvim.12295