Design and synthesis of novel quinoxaline derivatives as potential candidates for treatment of multidrug-resistant and latent tuberculosis

[Display omitted] Twenty-four quinoxaline derivatives were evaluated for their antimycobacterial activity using BacTiter-Glo microbial cell viability assay. Five compounds showed MIC values

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2016-05, Vol.26 (9), p.2188-2193
Hauptverfasser:	Santivañez-Veliz, Mery, Pérez-Silanes, Silvia, Torres, Enrique, Moreno-Viguri, Elsa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimycobacterial Antitubercular Agents - chemical synthesis Antitubercular Agents - pharmacology Cell Line Cyclic N-Oxides - chemistry Cyclic N-Oxides - pharmacology Drug Resistance, Multiple, Bacterial - drug effects Intracellular activity Latent Tuberculosis - drug therapy Mice Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Quinoxaline Quinoxalines - chemical synthesis Quinoxalines - chemistry Quinoxalines - pharmacology Tuberculosis Tuberculosis, Multidrug-Resistant - drug therapy
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Beschreibung
Zusammenfassung:	[Display omitted] Twenty-four quinoxaline derivatives were evaluated for their antimycobacterial activity using BacTiter-Glo microbial cell viability assay. Five compounds showed MIC values
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2016.03.066