The effects of anthocyanin-rich wheat diet on the oxidative status and behavior of rats
To evaluate the effect of food containing anthocyanin-rich wheat on oxidative status and behavior of healthy rats. Twenty male rats were divided into the control and anthocyanin group. Oral glucose tolerance test was performed, and proteinuria and creatinine clearance were measured. Behavioral analy...
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Veröffentlicht in: | Croatian medical journal 2016-04, Vol.57 (2), p.119-129 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | To evaluate the effect of food containing anthocyanin-rich wheat on oxidative status and behavior of healthy rats.
Twenty male rats were divided into the control and anthocyanin group. Oral glucose tolerance test was performed, and proteinuria and creatinine clearance were measured. Behavioral analysis was performed in Phenotyper cages. Serum and tissues were collected to measure the markers of oxidative stress and antioxidant status.
Anthocyanins significantly increased total antioxidant capacity in serum (P=0.039), decreased advanced oxidation protein products in the kidney (P=0.002), but increased thiobarbituric acid reactive substances in the kidney compared to the control group. No significant difference between the groups was found in the markers of oxidative stress in the liver and colon, as well as in renal functions and glucose metabolism. The anthocyanin group spent significantly less time in the spotlight zone of the Phenotyper cages (P=0.040), indicating higher anxiety-like behavior.
Food containing anthocyanin-rich wheat had positive effects on serum antioxidant status and kidney protein oxidation, but increased lipid peroxidation in the kidney and modified animal behavior related to anxiety. The molecular mechanisms leading to observed effects should be further elucidated. |
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ISSN: | 0353-9504 1332-8166 |
DOI: | 10.3325/cmj.2016.57.119 |