Unilateral microinjection of acrolein into thoracic spinal cord produces acute and chronic injury and functional deficits

Highlights • Acrolein microinjection produces dose-dependent tissue damage and motor deficits. • Acrolein microinjection induces gliotic response and macrophage invasion. • Acrolein could be an important contributor to secondary spinal cord injury. • Acrolein could be a target for therapeutic interv...

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Veröffentlicht in:	Neuroscience 2016-06, Vol.326, p.84-94
Hauptverfasser:	Gianaris, Alexander, Liu, Nai-Kui, Wang, Xiao-Fei, Oakes, Eddie, Brenia, John, Gianaris, Thomas, Ruan, Yiwen, Deng, Ling-Xiao, Goetz, Maria, Vega-Alvarez, Sasha, Lu, Qing-Bo, Shi, Riyi, Xu, Xiao-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	acrolein Acrolein - administration & dosage Acrolein - toxicity aldehyde Animals Astrocytes - drug effects Astrocytes - metabolism Axons - drug effects Axons - ultrastructure Dose-Response Relationship, Drug Female lipid peroxidation Locomotion - drug effects Myelin Sheath - drug effects Myelin Sheath - ultrastructure Neurology oxidative stress Rats Rats, Sprague-Dawley Spinal Cord Injuries - chemically induced Spinal Cord Injuries - pathology spinal cord injury
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Zusammenfassung:	Highlights • Acrolein microinjection produces dose-dependent tissue damage and motor deficits. • Acrolein microinjection induces gliotic response and macrophage invasion. • Acrolein could be an important contributor to secondary spinal cord injury. • Acrolein could be a target for therapeutic intervention.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2016.03.054