Continuing versus Stopping Prestroke Antihypertensive Therapy in Acute Intracerebral Hemorrhage: A Subgroup Analysis of the Efficacy of Nitric Oxide in Stroke Trial

Background and purpose More than 50% of patients with acute intracerebral hemorrhage (ICH) are taking antihypertensive drugs before ictus. Although antihypertensive therapy should be given long term for secondary prevention, whether to continue or stop such treatment during the acute phase of ICH re...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of stroke and cerebrovascular diseases 2016-05, Vol.25 (5), p.1017-1026
Hauptverfasser:	Krishnan, Kailash, MRCP, Scutt, Polly, MSc, Woodhouse, Lisa, MSc, Adami, Alessandro, MD, Becker, Jennifer L., MD, FRCR, Cala, Lesley A., MD, FRCR, Casado, Ana M., MD, Chen, Christopher, MRCP, FAMS, Dineen, Robert A., PhD, FRCR, Gommans, John, FRACP, Koumellis, Panos, MRCP, FRCR, Christensen, Hanna, MD, PhD, Collins, Ronan, MD, FRCPI, Czlonkowska, Anna, MD, PhD, Lees, Kennedy R., MD, FRCP, Ntaios, George, MD, PhD, Ozturk, Serefnur, MD, Phillips, Stephen J., MBBS, FRCPC, Sprigg, Nikola, DM, MRCP, Szatmari, Szabolcs, MD, Wardlaw, Joanna M., FRCR, FMedSci, Bath, Philip M., DSc, FRCP
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Antihypertensive Agents - administration & dosage Antihypertensive Agents - adverse effects Antihypertensive therapy blood pressure Blood Pressure - drug effects Cardiovascular cerebrovascular disorders Disability Evaluation Drug Administration Schedule Female glyceryl trinitrate Humans Hypertension - diagnosis Hypertension - drug therapy Hypertension - mortality Hypertension - physiopathology intracerebral hemorrhage Intracranial Hemorrhage, Hypertensive - diagnosis Intracranial Hemorrhage, Hypertensive - drug therapy Intracranial Hemorrhage, Hypertensive - mortality Intracranial Hemorrhage, Hypertensive - physiopathology Linear Models Logistic Models Male Middle Aged Multivariate Analysis Neurology Nitric Oxide Donors - administration & dosage Nitric Oxide Donors - adverse effects Nitroglycerin - administration & dosage Nitroglycerin - adverse effects Odds Ratio Proportional Hazards Models Prospective Studies randomized controlled trial Risk Factors Stroke - diagnosis Stroke - drug therapy Stroke - mortality Stroke - physiopathology Time Factors Treatment Outcome
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Background and purpose More than 50% of patients with acute intracerebral hemorrhage (ICH) are taking antihypertensive drugs before ictus. Although antihypertensive therapy should be given long term for secondary prevention, whether to continue or stop such treatment during the acute phase of ICH remains unclear, a question that was addressed in the Efficacy of Nitric Oxide in Stroke (ENOS) trial. Methods ENOS was an international multicenter, prospective, randomized, blinded endpoint trial. Among 629 patients with ICH and systolic blood pressure between 140 and 220 mmHg, 246 patients who were taking antihypertensive drugs were assigned to continue (n = 119) or to stop (n = 127) taking drugs temporarily for 7 days. The primary outcome was the modified Rankin Score at 90 days. Secondary outcomes included death, length of stay in hospital, discharge destination, activities of daily living, mood, cognition, and quality of life. Results Blood pressure level (baseline 171/92 mmHg) fell in both groups but was significantly lower at 7 days in those patients assigned to continue antihypertensive drugs (difference 9.4/3.5 mmHg, P
ISSN:	1052-3057 1532-8511
DOI:	10.1016/j.jstrokecerebrovasdis.2016.01.010