The p75 neurotrophin receptor augments survival signaling in the striatum of pre-symptomatic Q175WT/HD mice
Highlights • Increased survival signaling in pre-symptomatic Q175 mice abolished by p75 deletion. • Q175WT/HD ;p75−/− mice have decreased expression of XIAP, Bcl-XL, and DARPP-32. • Q175WT/HD ;p75−/− mice have a more advanced decrease in striatal volume.
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| Veröffentlicht in: | Neuroscience 2016-06, Vol.324, p.297-306 |
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| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
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| Online-Zugang: | Volltext |
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| Zusammenfassung: | Highlights • Increased survival signaling in pre-symptomatic Q175 mice abolished by p75 deletion. • Q175WT/HD ;p75−/− mice have decreased expression of XIAP, Bcl-XL, and DARPP-32. • Q175WT/HD ;p75−/− mice have a more advanced decrease in striatal volume. |
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| ISSN: | 0306-4522 1873-7544 |
| DOI: | 10.1016/j.neuroscience.2016.02.069 |