Relationship between the efficacy of oral antidiabetic drugs and clinical features in type 2 diabetic patients (JDDM38)

Aims/Introduction We carried out an observational cohort study to examine the relationship between the efficacy of oral antidiabetic drugs and clinical features in type 2 diabetics. Materials and Methods We analyzed the CoDiC® database of the Japan Diabetes Data Management Study Group across 67 inst...

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Veröffentlicht in:	Journal of diabetes investigation 2016-05, Vol.7 (3), p.386-395
Hauptverfasser:	Kanatsuka, Azuma, Sato, Yasunori, Kawai, Koichi, Hirao, Koichi, Kobayashi, Masashi, Kashiwagi, Atsunori, Abe, Nobuyuki, Arai, Keiko, Fujiya, Hiroshi, Fukumoto, Yoshihide, Dake, Fumihiko, Iizumi, Tomohiro, Ito, Masaaki, Iwasaki, Koichi, Kanamori, Akira, Kato, Sumio, Kato, Masakazu, Kawara, Akira, Kimura, Kenichi, Chikamori, Kazumasa, Iemitsu, Kotaro, Kou, Shigetake, Kudo, Mikihiko, Kurihara, Yoshio, Lee, Gendai, Tsuruoka, Akira, Manda, Naoki, Matoba, Kiyokazu, Hayashi, Hiroshi, Minami, Masae, Kuribayashi, Nobuichi, Miyazawa, Kazuhiro, Chiba, Yasuko, Osonoi, Takeshi, Nakamura, Shin, Sasaki, Hideo, Komori, Katsutoshi, Oishi, Mariko, Okada, Akira, Okuguchi, Fuminobu, Yanagisawa, Morifumi, Sugimoto, Hidekatsu, Sugiyama, Hiromichi, Takai, Masahiko, Takaki, Masato, Takamura, Hiroshi, Takeda, Hiroshi, Tanaka, Kokichi, Miwa, Takashi, Tomonaga, Osamu, Taguchi, Madoka, Yamazaki, Katsuya, Wada, Takako, Yagi, Noriharu, Yamaoka, Kuniko, Yuhara, Atsuyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Aged Antidiabetics Bias Body Mass Index Cohort analysis Cohort Studies Committees Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - metabolism Dipeptidyl-peptidase IV Dipeptidyl-Peptidase IV Inhibitors - administration & dosage Dipeptidyl-Peptidase IV Inhibitors - therapeutic use Drug therapy Female Glycated Hemoglobin - metabolism Hemoglobin Humans Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - therapeutic use Male Metformin Metformin - administration & dosage Metformin - therapeutic use Methods Middle Aged Oral antidiabetic drug Original Patients Peptidase Propensity Score Propensity score‐matched cohort study Software Standardization Studies Sulfonylurea Sulfonylurea Compounds - administration & dosage Sulfonylurea Compounds - therapeutic use Treatment Outcome Type 2 diabetes mellitus Variance analysis
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Zusammenfassung:	Aims/Introduction We carried out an observational cohort study to examine the relationship between the efficacy of oral antidiabetic drugs and clinical features in type 2 diabetics. Materials and Methods We analyzed the CoDiC® database of the Japan Diabetes Data Management Study Group across 67 institutions in Japan. In a total of 3,698 drug‐naïve patients who were initiated with metformin, dipeptidyl peptidase‐4 inhibitor (DPP‐4i) or sulfonylurea (SU) from 2007 to 2012, we evaluated body mass index (BMI) and hemoglobin A1c (HbA1c). The patients were stratified according to their clinical features, and matched using a propensity score to adjust for baseline factors. Results HbA1c was reduced with all drugs, with the largest effect elicited by DPP‐4i and the smallest by SU (P = 0.00). HbA1c increased with SU after 6 months in the patients stratified by an age‐of‐onset of
ISSN:	2040-1116 2040-1124
DOI:	10.1111/jdi.12430