Sleeping Beauty transposon screen identifies signaling modules that cooperate with STAT5 activation to induce B-cell acute lymphoblastic leukemia

Signal transducer and activator of transcription 5 (STAT5) activation occurs frequently in human progenitor B-cell acute lymphoblastic leukemia (B-ALL). To identify gene alterations that cooperate with STAT5 activation to initiate leukemia, we crossed mice expressing a constitutively active form of...

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Veröffentlicht in:	Oncogene 2016-06, Vol.35 (26), p.3454-3464
Hauptverfasser:	Heltemes-Harris, L M, Larson, J D, Starr, T K, Hubbard, G K, Sarver, A L, Largaespada, D A, Farrar, M A
Format:	Artikel
Sprache:	eng
Schlagworte:	45/23 631/208/68 631/250/1619 631/67/69 96/31 Acute lymphoblastic leukemia Acute lymphocytic leukemia Animals Apoptosis B-Lymphocytes - metabolism Blotting, Western Cell activation Cell Biology Cell differentiation Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cellular signal transduction Development and progression DNA Transposable Elements - genetics Experiments Extracellular signal-regulated kinase Gene expression Gene Expression Regulation, Leukemic Genetic aspects Health aspects Human Genetics Ikaros Transcription Factor - genetics Ikaros Transcription Factor - metabolism Internal Medicine Janus kinase Janus Kinase 1 - genetics Janus Kinase 1 - metabolism Jumonji Domain-Containing Histone Demethylases - genetics Jumonji Domain-Containing Histone Demethylases - metabolism Kaplan-Meier Estimate Leukemia Lymphatic leukemia Lymphocytes B Medicine Medicine & Public Health Mice, Inbred C57BL Mice, Transgenic Mutagenesis, Insertional Mutation Next-generation sequencing Oncology original-article p38 Mitogen-Activated Protein Kinases - metabolism Polycomb Repressive Complex 1 - genetics Polycomb Repressive Complex 1 - metabolism Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - pathology Properties Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Reverse Transcriptase Polymerase Chain Reaction SOS1 Protein - genetics SOS1 Protein - metabolism Stat5 protein STAT5 Transcription Factor - genetics STAT5 Transcription Factor - metabolism Transcription activation Transcription factors Transposons Tumors
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Zusammenfassung:	Signal transducer and activator of transcription 5 (STAT5) activation occurs frequently in human progenitor B-cell acute lymphoblastic leukemia (B-ALL). To identify gene alterations that cooperate with STAT5 activation to initiate leukemia, we crossed mice expressing a constitutively active form of STAT5 ( Stat5b-CA ) with mice in which a mutagenic Sleeping Beauty transposon ( T2/Onc ) was mobilized only in B cells. Stat5b-CA mice typically do not develop B-ALL (
ISSN:	0950-9232 1476-5594
DOI:	10.1038/onc.2015.405