Angina in McArdle's disease

McArdle's disease (myophosphorylase deficiency) results in the inability to metabolise skeletal muscle glycogen to lactate. A patient with this condition developed angina and therefore offered a unique opportunity to explore the differential expression of the defective myophosphorylase gene in...

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Veröffentlicht in:	Heart (British Cardiac Society) 1996-10, Vol.76 (4), p.372-373
Hauptverfasser:	Nicholls, D. P., Campbell, N. P., Stevenson, H. P., Patterson, V. H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Angina Pectoris - blood Angina Pectoris - complications Angina Pectoris - enzymology Biological and medical sciences Carbohydrates (enzymatic deficiencies). Glycogenosis Cardiac Pacing, Artificial Electrophoresis, Polyacrylamide Gel Errors of metabolism Gene Expression Glycogen Storage Disease Type V - blood Glycogen Storage Disease Type V - complications Glycogen Storage Disease Type V - enzymology Humans Isoenzymes Lactic Acid - blood Male Medical sciences Metabolic diseases Muscle, Skeletal - enzymology Myocardium - enzymology Phosphorylases - analysis Phosphorylases - genetics
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Beschreibung
Zusammenfassung:	McArdle's disease (myophosphorylase deficiency) results in the inability to metabolise skeletal muscle glycogen to lactate. A patient with this condition developed angina and therefore offered a unique opportunity to explore the differential expression of the defective myophosphorylase gene in skeletal and cardiac muscle.
ISSN:	1355-6037 1468-201X
DOI:	10.1136/hrt.76.4.372