Abnormal glycemic homeostasis at the onset of serious mental illnesses: A common pathway

Highlights • Patients with serious mental illnesses present an abnormal glycemic state at onset. • A pre-diabetic state might explain the increased morbidity and mortality over time. • A theoretical explanation relies on the high prevalence of obstetric complications. • Early life stressful events w...

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Veröffentlicht in:	Psychoneuroendocrinology 2016-05, Vol.67, p.70-75
Hauptverfasser:	Garcia-Rizo, Clemente, Kirkpatrick, Brian, Fernandez-Egea, Emilio, Oliveira, Cristina, Bernardo, Miquel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjustment Disorders - blood Adult Bipolar disorder Bipolar Disorder - blood Blood Glucose Case-Control Studies Depressive Disorder, Major - blood Depressió psíquica Endocrinology & Metabolism Esquizofrènia Female Glucose Tolerance Test Homeostasis Humans Major depressive disorder Male Manic-depressive illness Mental depression Mortalitat Mortality Psychiatry Schizophrenia Schizophrenia - blood Thrifty psychiatric phenotype Trastorn bipolar Type 2 diabetes mellitus Young Adult
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Zusammenfassung:	Highlights • Patients with serious mental illnesses present an abnormal glycemic state at onset. • A pre-diabetic state might explain the increased morbidity and mortality over time. • A theoretical explanation relies on the high prevalence of obstetric complications. • Early life stressful events would predict metabolic disturbances ongoing at onset.
ISSN:	0306-4530 1873-3360
DOI:	10.1016/j.psyneuen.2016.02.001