Modeling the potential impact of vaccination on the epidemiology of congenital cytomegalovirus infection

Modeling the potential impact of vaccination on the epidemiology of congenital cytomegalovirus infection

Highlights • We model impact of cytomegalovirus (CMV) vaccination in the U.S. and Brazil. • We estimate change in congenital infections overall and by maternal infection type. • Greater reductions with vaccination of young children than adults. • Vaccination of infants could eliminate congenital CMV...

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Veröffentlicht in:Vaccine 2014-06, Vol.32 (30), p.3780-3786
Hauptverfasser: Lanzieri, Tatiana M, Bialek, Stephanie R, Ortega-Sanchez, Ismael R, Gambhir, Manoj
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adolescents
Adult
Allergy and Immunology
Applied microbiology
Biological and medical sciences
Brazil - epidemiology
Child
Child, Preschool
Congenital infection
Cytomegalovirus
Cytomegalovirus Infections - congenital
Cytomegalovirus Infections - epidemiology
Cytomegalovirus Infections - prevention & control
Cytomegalovirus Vaccines - therapeutic use
Epidemiology
Female
Fundamental and applied biological sciences. Psychology
Humans
Immunization
Infant
Infectious Disease Transmission, Vertical - prevention & control
Mathematical model
Microbiology
Miscellaneous
Models, Theoretical
Pregnancy
United States - epidemiology
Vaccination - methods
Vaccination impact
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Virology
Young Adult
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Beschreibung
Zusammenfassung:Highlights • We model impact of cytomegalovirus (CMV) vaccination in the U.S. and Brazil. • We estimate change in congenital infections overall and by maternal infection type. • Greater reductions with vaccination of young children than adults. • Vaccination of infants could eliminate congenital CMV infection. • Under certain scenarios congenital infection from primary maternal infection may increase.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2014.05.014