Risk of non-hematologic cancer in individuals with high-count monoclonal B-cell lymphocytosis

It is unknown whether individuals with monoclonal B-cell lymphocytosis (MBL) are at risk for adverse outcomes associated with chronic lymphocytic leukemia (CLL), such as the risk of non-hematologic cancer. We identified all locally residing individuals diagnosed with high-count MBL at Mayo Clinic be...

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Veröffentlicht in:Leukemia 2016-02, Vol.30 (2), p.331-336
Hauptverfasser: Solomon, B M, Chaffee, K G, Moreira, J, Schwager, S M, Cerhan, J R, Call, T G, Kay, N E, Slager, S L, Shanafelt, T D
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Sprache:eng
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Zusammenfassung:It is unknown whether individuals with monoclonal B-cell lymphocytosis (MBL) are at risk for adverse outcomes associated with chronic lymphocytic leukemia (CLL), such as the risk of non-hematologic cancer. We identified all locally residing individuals diagnosed with high-count MBL at Mayo Clinic between 1999 and 2009 and compared their rates of non-hematologic cancer with that of patients with CLL and two control cohorts: general medicine patients and patients who underwent clinical evaluation with flow cytometry but who had no hematologic malignancy. After excluding individuals with prior cancers, there were 107 high-count MBL cases, 132 CLL cases, 589 clinic controls and 482 flow cytometry controls. With 4.6 years median follow-up, 14 (13%) individuals with high-count MBL, 21 (4%) clinic controls (comparison MBL P
ISSN:0887-6924
1476-5551
DOI:10.1038/leu.2015.235