KIAA1522 is a novel prognostic biomarker in patients with non-small cell lung cancer

Nowadays, no robust biomarkers have been applied to clinical practice to provide prognostic evaluation of non-small cell lung cancer (NSCLC). This study aims to identify new potential prognostic biomarkers for NSCLC. In the present work, KIAA1522 is screened out from two independent GEO datasets as...

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Veröffentlicht in:	Scientific reports 2016-04, Vol.6 (1), p.24786-24786, Article 24786
Hauptverfasser:	Liu, Yi-Zhen, Yang, Hai, Cao, Jian, Jiang, Yan-Yi, Hao, Jia-Jie, Xu, Xin, Cai, Yan, Wang, Ming-Rong
Format:	Artikel
Sprache:	eng
Schlagworte:	13/105 38/77 631/67/1612/1350 631/67/1857 Adult Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biomarkers Biomarkers, Tumor Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - mortality Chemotherapy Female Gene Expression Regulation, Neoplastic Gene set enrichment analysis Humanities and Social Sciences Humans K-Ras protein Kaplan-Meier Estimate Lung cancer Lung Neoplasms - genetics Lung Neoplasms - mortality Male Middle Aged multidisciplinary Non-small cell lung carcinoma Platinum Prognosis Proportional Hazards Models Proto-Oncogene Proteins p21(ras) - genetics Proto-Oncogene Proteins p21(ras) - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Science Signal Transduction Survival Treatment Outcome
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Zusammenfassung:	Nowadays, no robust biomarkers have been applied to clinical practice to provide prognostic evaluation of non-small cell lung cancer (NSCLC). This study aims to identify new potential prognostic biomarkers for NSCLC. In the present work, KIAA1522 is screened out from two independent GEO datasets as aberrantly up-regulated gene in NSCLC tissues. We evaluate KIAA1522 expression immunohistochemically in 583 NSCLC tissue samples and paired non-tumor tissues. KIAA1522 displays stronger staining in NSCLC cases than in adjacent normal lung tissues. Importantly, patients with KIAA1522 overexpression had a significantly shorter overall survival compared to those with low expression ( P
ISSN:	2045-2322 2045-2322
DOI:	10.1038/srep24786