Incubation of cocaine cue reactivity associates with neuroadaptations in the cortical serotonin (5-HT) 5-HT2C receptor (5-HT2C R) system

Highlights • Cue reactivity incubates during forced abstinence from cocaine- or sucrose-taking. • Incubation aligns with lower potency of 5-HT2C R agonist to suppress cocaine cue reactivity. • Incubation of cocaine cue reactivity associates with lower 5-HT2C R expression in mPFC. • Membrane to cytop...

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Veröffentlicht in:	Neuroscience 2016-06, Vol.324, p.50-61
Hauptverfasser:	Swinford-Jackson, S.E, Anastasio, N.C, Fox, R.G, Stutz, S.J, Cunningham, K.A
Format:	Artikel
Sprache:	eng
Schlagworte:	5-HT2C receptor Animals Attention - drug effects Attention - physiology Azepines - pharmacology Cell Membrane - drug effects Cell Membrane - metabolism cocaine Cocaine - administration & dosage Cocaine-Related Disorders - metabolism Cohort Studies Conditioning, Operant - drug effects Conditioning, Operant - physiology cue reactivity Cues Cytoplasm - drug effects Cytoplasm - metabolism Dietary Sucrose - administration & dosage Dopamine Uptake Inhibitors - administration & dosage Drug-Seeking Behavior - drug effects Drug-Seeking Behavior - physiology incubation Indoles - pharmacology Male medial prefrontal cortex Neurology Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Rats, Sprague-Dawley Receptor, Serotonin, 5-HT2C - metabolism RNA, Messenger - metabolism Self Administration Serotonin 5-HT2 Receptor Agonists - pharmacology Substance Withdrawal Syndrome - drug therapy Substance Withdrawal Syndrome - metabolism sucrose Time Factors
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Zusammenfassung:	Highlights • Cue reactivity incubates during forced abstinence from cocaine- or sucrose-taking. • Incubation aligns with lower potency of 5-HT2C R agonist to suppress cocaine cue reactivity. • Incubation of cocaine cue reactivity associates with lower 5-HT2C R expression in mPFC. • Membrane to cytoplasmic 5-HT2C R ratio inversely correlates with cocaine cue reactivity.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2016.02.052