Exogenous ceramide-1-phosphate (C1P) and phospho-ceramide analogue-1 (PCERA-1) regulate key macrophage activities via distinct receptors

Highlights • C1P and the synthetic analog PCERA-1 affect macrophages via distinct receptors. • TNFα secretion is inhibited at different stages by exogenous C1P and PCERA-1. • Exogenous C1P inhibits TNFα secretion at the level of TACE activity. • PCERA-1 reciprocally modulates TNFα and IL-10 transcri...

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Veröffentlicht in:	Immunology letters 2016-01, Vol.169, p.73-81
Hauptverfasser:	Katz, Sebastián, Ernst, Orna, Avni, Dorit, Athamna, Muhammad, Philosoph, Amir, Arana, Lide, Ouro, Alberto, Hoeferlin, L. Alexis, Meijler, Michael M, Chalfant, Charles E, Gómez-Muñoz, Antonio, Zor, Tsaffrir
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM Proteins - metabolism ADAM17 Protein Allergy and Immunology Animals C1P Cell Line Cell Movement - drug effects Ceramides - pharmacology Cyclic AMP - metabolism Cyclic AMP Response Element-Binding Protein - metabolism Drug Synergism Gene Expression Regulation - drug effects IL-10 Inflammation Inflammation - drug therapy Inflammation - immunology Interleukin-10 - genetics Interleukin-10 - metabolism Lipopolysaccharides - immunology Macrophages Macrophages - drug effects Macrophages - immunology Mice Migration Receptors, G-Protein-Coupled - metabolism Signal Transduction - drug effects TNFα Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism
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Zusammenfassung:	Highlights • C1P and the synthetic analog PCERA-1 affect macrophages via distinct receptors. • TNFα secretion is inhibited at different stages by exogenous C1P and PCERA-1. • Exogenous C1P inhibits TNFα secretion at the level of TACE activity. • PCERA-1 reciprocally modulates TNFα and IL-10 transcription via CREB.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2015.12.001