The redox state of the alarmin HMGB1 is a pivotal factor in neuroinflammatory and microglial priming: A role for the NLRP3 inflammasome

The redox state of the alarmin HMGB1 is a pivotal factor in neuroinflammatory and microglial priming: A role for the NLRP3 inflammasome

Highlights • ds-HMGB1 induced NF-κBIα and NLRP3 expression in hippocampus and microglia. • ds-HMGB1 potentiated the neuroinflammatory and sickness response to LPS. • ds-HMGB1 primed the microglial proinflammatory response to an immune challenge. • fr-HMGB1 had no effect on neuroinflammatory or micro...

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Veröffentlicht in:Brain, behavior, and immunity behavior, and immunity, 2016-07, Vol.55, p.215-224
Hauptverfasser: Frank, Matthew G, Weber, Michael D, Fonken, Laura K, Hershman, Sarah A, Watkins, Linda R, Maier, Steven F
Format: Artikel
Sprache:eng
Schlagworte:
Alarmins - immunology
Allergy and Immunology
Animals
Hippocampus - immunology
HMGB1
HMGB1 Protein - administration & dosage
HMGB1 Protein - pharmacology
Inflammasomes - immunology
Inflammation - immunology
Inflammation Mediators - immunology
Male
Microglia
Microglia - immunology
Neuroinflammation
NLR Family, Pyrin Domain-Containing 3 Protein
Oxidation-Reduction
Priming
Psychiatry
Rats
Rats, Sprague-Dawley
Redox state
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Zusammenfassung:Highlights • ds-HMGB1 induced NF-κBIα and NLRP3 expression in hippocampus and microglia. • ds-HMGB1 potentiated the neuroinflammatory and sickness response to LPS. • ds-HMGB1 primed the microglial proinflammatory response to an immune challenge. • fr-HMGB1 had no effect on neuroinflammatory or microglial priming.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2015.10.009