Chromosomal copy number alterations and HPV integration in cervical precancer and invasive cancer
The relationship between chromosomal instability and integration of the human papillomavirus (HPV) DNA into the host genome is not well understood. We found that chromosomal instability increases with HPV integration and diagnosis. However, chromosomal instability could occur without HPV integration...
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| Veröffentlicht in: | Carcinogenesis (New York) 2016-02, Vol.37 (2), p.188-196 |
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| container_title | Carcinogenesis (New York) |
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| creator | Bodelon, Clara Vinokurova, Svetlana Sampson, Joshua N den Boon, Johan A Walker, Joan L Horswill, Mark A Korthauer, Keegan Schiffman, Mark Sherman, Mark E Zuna, Rosemary E Mitchell, Jason Zhang, Xijun Boland, Joseph F Chaturvedi, Anil K Dunn, S Terence Newton, Michael A Ahlquist, Paul Wang, Sophia S Wentzensen, Nicolas |
| description | The relationship between chromosomal instability and integration of the human papillomavirus (HPV) DNA into the host genome is not well understood. We found that chromosomal instability increases with HPV integration and diagnosis. However, chromosomal instability could occur without HPV integration. |
| doi_str_mv | 10.1093/carcin/bgv171 |
| format | Article |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Adult Cervical Intraepithelial Neoplasia - genetics Cervical Intraepithelial Neoplasia - virology Cluster Analysis Comparative Genomic Hybridization Female Gene Dosage Genomic Instability Human papillomavirus 16 Humans Laser Capture Microdissection Middle Aged Original Manuscript Papillomavirus Infections - virology Polymerase Chain Reaction Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - virology Virus Integration - genetics |
| title | Chromosomal copy number alterations and HPV integration in cervical precancer and invasive cancer |
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