Chromosomal copy number alterations and HPV integration in cervical precancer and invasive cancer

The relationship between chromosomal instability and integration of the human papillomavirus (HPV) DNA into the host genome is not well understood. We found that chromosomal instability increases with HPV integration and diagnosis. However, chromosomal instability could occur without HPV integration...

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Veröffentlicht in:	Carcinogenesis (New York) 2016-02, Vol.37 (2), p.188-196
Hauptverfasser:	Bodelon, Clara, Vinokurova, Svetlana, Sampson, Joshua N, den Boon, Johan A, Walker, Joan L, Horswill, Mark A, Korthauer, Keegan, Schiffman, Mark, Sherman, Mark E, Zuna, Rosemary E, Mitchell, Jason, Zhang, Xijun, Boland, Joseph F, Chaturvedi, Anil K, Dunn, S Terence, Newton, Michael A, Ahlquist, Paul, Wang, Sophia S, Wentzensen, Nicolas
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Cervical Intraepithelial Neoplasia - genetics Cervical Intraepithelial Neoplasia - virology Cluster Analysis Comparative Genomic Hybridization Female Gene Dosage Genomic Instability Human papillomavirus 16 Humans Laser Capture Microdissection Middle Aged Original Manuscript Papillomavirus Infections - virology Polymerase Chain Reaction Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - virology Virus Integration - genetics
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Zusammenfassung:	The relationship between chromosomal instability and integration of the human papillomavirus (HPV) DNA into the host genome is not well understood. We found that chromosomal instability increases with HPV integration and diagnosis. However, chromosomal instability could occur without HPV integration.
ISSN:	0143-3334 1460-2180
DOI:	10.1093/carcin/bgv171