Generalized Manning Condensation Model Captures the RNA Ion Atmosphere

RNA is highly sensitive to the ionic environment and typically requires Mg(2+) to form compact structures. There is a need for models capable of describing the ion atmosphere surrounding RNA with quantitative accuracy. We present a model of RNA electrostatics and apply it within coarse-grained molec...

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Veröffentlicht in:	Physical review letters 2015-06, Vol.114 (25), p.258105-258105
Hauptverfasser:	Hayes, Ryan L, Noel, Jeffrey K, Mandic, Ana, Whitford, Paul C, Sanbonmatsu, Karissa Y, Mohanty, Udayan, Onuchic, José N
Format:	Artikel
Sprache:	eng
Schlagworte:	Atmospheres Cations, Monovalent - chemistry Computer simulation Condensing Free energy Landscapes Magnesium - chemistry Mathematical models Models, Chemical Molecular dynamics Nucleic Acid Conformation Ribonucleic acids RNA - chemistry Static Electricity
Online-Zugang:	Volltext
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