E11/Podoplanin Protein Stabilization Through Inhibition of the Proteasome Promotes Osteocyte Differentiation in Murine in Vitro Models

The transmembrane glycoprotein E11 is considered critical in early osteoblast–osteocyte transitions (osteocytogenesis), however its function and regulatory mechanisms are still unknown. Using the late osteoblast MLO‐A5 cell line we reveal increased E11 protein/mRNA expression (P

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of cellular physiology 2016-06, Vol.231 (6), p.1392-1404
Hauptverfasser:	Staines, Katherine A., Prideaux, Matt, Allen, Steve, Buttle, David J., Pitsillides, Andrew A., Farquharson, Colin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calpain - antagonists & inhibitors Calpain - metabolism Cell Differentiation - drug effects Cell Line Cysteine Proteinase Inhibitors - pharmacology Dendrites Dose-Response Relationship, Drug Inhibitors Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Mice, Inbred C57BL Mineralization Original Original s Osteoblasts - drug effects Osteoblasts - enzymology Osteocytes - drug effects Osteocytes - enzymology Phenotype Proteasome Endopeptidase Complex - metabolism Proteasome Inhibitors - pharmacology Protein Stability Proteolysis rho GTP-Binding Proteins - metabolism rhoA GTP-Binding Protein RNA, Messenger - metabolism Time Factors Transfection Ubiquitination
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Beschreibung
Zusammenfassung:	The transmembrane glycoprotein E11 is considered critical in early osteoblast–osteocyte transitions (osteocytogenesis), however its function and regulatory mechanisms are still unknown. Using the late osteoblast MLO‐A5 cell line we reveal increased E11 protein/mRNA expression (P
ISSN:	0021-9541 1097-4652
DOI:	10.1002/jcp.25282