Genipin cross-linked decellularized tracheal tubular matrix for tracheal tissue engineering applications

Genipin cross-linked decellularized tracheal tubular matrix for tracheal tissue engineering applications

Decellularization techniques have been widely used as an alternative strategy for organ reconstruction. This study investigated the mechanical, pro-angiogenic and in vivo biocompatibility properties of decellularized airway matrices cross-linked with genipin. New Zealand rabbit tracheae were decellu...

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Veröffentlicht in:Scientific reports 2016-04, Vol.6 (1), p.24429-24429, Article 24429
Hauptverfasser: Sun, Fei, Jiang, Yuan, Xu, Yanfei, Shi, Hongcan, Zhang, Siquan, Liu, Xingchen, Pan, Shu, Ye, Gang, Zhang, Weidong, Zhang, Fangbiao, Zhong, Chonghao
Format: Artikel
Sprache:eng
Schlagworte:
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Angiogenesis
Animal models
Animals
Biocompatibility
Biocompatible Materials - chemistry
Biomechanical Phenomena
Chick Embryo
Extracellular Matrix - chemistry
Genipin
Heterografts
Humanities and Social Sciences
Immunoglobulin G
Immunoglobulin M
Inflammation
Iridoids - chemistry
Male
Materials Testing
Mechanical properties
multidisciplinary
Neovascularization, Physiologic
Rabbits
Rats
Respiratory tract
Rodents
Science
Tissue Engineering
Tissue Scaffolds
Trachea - chemistry
Xenografts
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Zusammenfassung:Decellularization techniques have been widely used as an alternative strategy for organ reconstruction. This study investigated the mechanical, pro-angiogenic and in vivo biocompatibility properties of decellularized airway matrices cross-linked with genipin. New Zealand rabbit tracheae were decellularized and cross-linked with genipin, a naturally derived agent. The results demonstrated that, a significant (p 
ISSN:2045-2322
2045-2322
DOI:10.1038/srep24429