Neutrophil depletion after subarachnoid hemorrhage improves memory via NMDA receptors
Highlights • Delayed deterioration after SAH is associated with poor cognitive outcomes. • In a murine model, SAH leads to delayed loss of NMDA mediated L-LTP. • Changes in L-LTP are associated with changes in NMDA NR2 subunit proportions. • Selective neutrophil depletion 3 days after SAH recovers N...
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| Veröffentlicht in: | Brain, behavior, and immunity behavior, and immunity, 2016-05, Vol.54, p.233-242 |
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| container_title | Brain, behavior, and immunity |
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| creator | Provencio, Jose Javier Swank, Valerie Lu, Haiyan Brunet, Sylvain Baltan, Selva Khapre, Rohini V Seerapu, Himabindu Kokiko-Cochran, Olga N Lamb, Bruce T Ransohoff, Richard M |
| description | Highlights • Delayed deterioration after SAH is associated with poor cognitive outcomes. • In a murine model, SAH leads to delayed loss of NMDA mediated L-LTP. • Changes in L-LTP are associated with changes in NMDA NR2 subunit proportions. • Selective neutrophil depletion 3 days after SAH recovers NMDA function. • Behavioral outcomes are improved by late neutrophil depletion. |
| doi_str_mv | 10.1016/j.bbi.2016.02.007 |
| format | Article |
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All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c539t-364b6308489eaec1f16f7ebb64b5e5d85b6a95bf0fe731890cdf77dd180f8b5e3</citedby><cites>FETCH-LOGICAL-c539t-364b6308489eaec1f16f7ebb64b5e5d85b6a95bf0fe731890cdf77dd180f8b5e3</cites><orcidid>0000-0002-5306-1275 ; 0000-0003-1298-1806</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0889159116300290$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26872422$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Provencio, Jose Javier</creatorcontrib><creatorcontrib>Swank, Valerie</creatorcontrib><creatorcontrib>Lu, Haiyan</creatorcontrib><creatorcontrib>Brunet, Sylvain</creatorcontrib><creatorcontrib>Baltan, Selva</creatorcontrib><creatorcontrib>Khapre, Rohini V</creatorcontrib><creatorcontrib>Seerapu, Himabindu</creatorcontrib><creatorcontrib>Kokiko-Cochran, Olga N</creatorcontrib><creatorcontrib>Lamb, Bruce T</creatorcontrib><creatorcontrib>Ransohoff, Richard M</creatorcontrib><title>Neutrophil depletion after subarachnoid hemorrhage improves memory via NMDA receptors</title><title>Brain, behavior, and immunity</title><addtitle>Brain Behav Immun</addtitle><description>Highlights • Delayed deterioration after SAH is associated with poor cognitive outcomes. • In a murine model, SAH leads to delayed loss of NMDA mediated L-LTP. • Changes in L-LTP are associated with changes in NMDA NR2 subunit proportions. • Selective neutrophil depletion 3 days after SAH recovers NMDA function. • Behavioral outcomes are improved by late neutrophil depletion.</description><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Cerebral vasospasm</subject><subject>Delayed neurological deterioration after subarachnoid hemorrhage</subject><subject>Immunity, Innate - immunology</subject><subject>Innate inflammation</subject><subject>Long-Term Potentiation - physiology</subject><subject>Male</subject><subject>Memory - physiology</subject><subject>Memory deficits</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Neutrophils</subject><subject>Neutrophils - pathology</subject><subject>Psychiatry</subject><subject>Receptors, N-Methyl-D-Aspartate - metabolism</subject><subject>Subarachnoid hemorrhage</subject><subject>Subarachnoid Hemorrhage - blood</subject><subject>Subarachnoid Hemorrhage - therapy</subject><subject>Vasospasm, Intracranial - therapy</subject><issn>0889-1591</issn><issn>1090-2139</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk9v1DAQxS0EotvCB-CCcuSSMLbjxBFSpaqlgNQ_B9qz5TiTxksSBztZab89jratgAPiZGv83tN4fkPIOwoZBVp83GZ1bTMWrxmwDKB8QTYUKkgZ5dVLsgEpq5SKih6R4xC2ACA4la_JEStkyXLGNuT-BpfZu6mzfdLg1ONs3ZjodkafhKXWXptudLZJOhyc951-wMQOk3c7DMmw1vbJzurk5vriLPFocJqdD2_Iq1b3Ad8-nifk_vLz3fnX9Or2y7fzs6vUCF7NKS_yuuAgc1mhRkNbWrQl1nUsCxSNFHWhK1G30GIZG6_ANG1ZNg2V0Moo4Sfk9JA7LfWAjcFx9rpXk7eD9nvltFV_voy2Uw9up3LJJKciBnx4DPDu54JhVoMNBvtej-iWoGgpBWM5F_x_pCBozvkqpQep8S4Ej-1zRxTUSk5tVSSnVnIKmIrkouf97195djyhioJPBwHGge4sehWMxdFgY-PcZ9U4-8_407_cprejNbr_gXsMW7f4MZJSVIVoUN_X1Vk3h0Y-wCrgvwCs5sAX</recordid><startdate>20160501</startdate><enddate>20160501</enddate><creator>Provencio, Jose Javier</creator><creator>Swank, Valerie</creator><creator>Lu, Haiyan</creator><creator>Brunet, Sylvain</creator><creator>Baltan, Selva</creator><creator>Khapre, Rohini V</creator><creator>Seerapu, Himabindu</creator><creator>Kokiko-Cochran, Olga N</creator><creator>Lamb, Bruce T</creator><creator>Ransohoff, Richard M</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QG</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5306-1275</orcidid><orcidid>https://orcid.org/0000-0003-1298-1806</orcidid></search><sort><creationdate>20160501</creationdate><title>Neutrophil depletion after subarachnoid hemorrhage improves memory via NMDA receptors</title><author>Provencio, Jose Javier ; 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| ispartof | Brain, behavior, and immunity, 2016-05, Vol.54, p.233-242 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Allergy and Immunology Animals Cerebral vasospasm Delayed neurological deterioration after subarachnoid hemorrhage Immunity, Innate - immunology Innate inflammation Long-Term Potentiation - physiology Male Memory - physiology Memory deficits Mice Mice, Inbred C57BL Neutrophils Neutrophils - pathology Psychiatry Receptors, N-Methyl-D-Aspartate - metabolism Subarachnoid hemorrhage Subarachnoid Hemorrhage - blood Subarachnoid Hemorrhage - therapy Vasospasm, Intracranial - therapy |
| title | Neutrophil depletion after subarachnoid hemorrhage improves memory via NMDA receptors |
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