Neutrophil depletion after subarachnoid hemorrhage improves memory via NMDA receptors

Highlights • Delayed deterioration after SAH is associated with poor cognitive outcomes. • In a murine model, SAH leads to delayed loss of NMDA mediated L-LTP. • Changes in L-LTP are associated with changes in NMDA NR2 subunit proportions. • Selective neutrophil depletion 3 days after SAH recovers N...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2016-05, Vol.54, p.233-242
Hauptverfasser:	Provencio, Jose Javier, Swank, Valerie, Lu, Haiyan, Brunet, Sylvain, Baltan, Selva, Khapre, Rohini V, Seerapu, Himabindu, Kokiko-Cochran, Olga N, Lamb, Bruce T, Ransohoff, Richard M
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Cerebral vasospasm Delayed neurological deterioration after subarachnoid hemorrhage Immunity, Innate - immunology Innate inflammation Long-Term Potentiation - physiology Male Memory - physiology Memory deficits Mice Mice, Inbred C57BL Neutrophils Neutrophils - pathology Psychiatry Receptors, N-Methyl-D-Aspartate - metabolism Subarachnoid hemorrhage Subarachnoid Hemorrhage - blood Subarachnoid Hemorrhage - therapy Vasospasm, Intracranial - therapy
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Zusammenfassung:	Highlights • Delayed deterioration after SAH is associated with poor cognitive outcomes. • In a murine model, SAH leads to delayed loss of NMDA mediated L-LTP. • Changes in L-LTP are associated with changes in NMDA NR2 subunit proportions. • Selective neutrophil depletion 3 days after SAH recovers NMDA function. • Behavioral outcomes are improved by late neutrophil depletion.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2016.02.007