Cognitive deficits develop 1 month after diffuse brain injury and are exaggerated by microglia-associated reactivity to peripheral immune challenge

Highlights • Inflammatory processes worsen with time after a brain injury and are likely mediated by glia. • Primed microglia detected 1-month following TBI, coinciding with detection of cognitive deficits. • Immune challenge augmented cognitive deficits after TBI associated with microglial reactivi...

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Veröffentlicht in:Brain, behavior, and immunity behavior, and immunity, 2016-05, Vol.54, p.95-109
Hauptverfasser: Muccigrosso, Megan M, Ford, Joni, Benner, Brooke, Moussa, Daniel, Burnsides, Christopher, Fenn, Ashley M, Popovich, Phillip G, Lifshitz, Jonathan, Walker, Fredrick Rohan, Eiferman, Daniel S, Godbout, Jonathan P
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Sprache:eng
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Zusammenfassung:Highlights • Inflammatory processes worsen with time after a brain injury and are likely mediated by glia. • Primed microglia detected 1-month following TBI, coinciding with detection of cognitive deficits. • Immune challenge augmented cognitive deficits after TBI associated with microglial reactivity.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2016.01.009