Cognitive deficits develop 1 month after diffuse brain injury and are exaggerated by microglia-associated reactivity to peripheral immune challenge
Highlights • Inflammatory processes worsen with time after a brain injury and are likely mediated by glia. • Primed microglia detected 1-month following TBI, coinciding with detection of cognitive deficits. • Immune challenge augmented cognitive deficits after TBI associated with microglial reactivi...
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Veröffentlicht in: | Brain, behavior, and immunity behavior, and immunity, 2016-05, Vol.54, p.95-109 |
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Hauptverfasser: | , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | Highlights • Inflammatory processes worsen with time after a brain injury and are likely mediated by glia. • Primed microglia detected 1-month following TBI, coinciding with detection of cognitive deficits. • Immune challenge augmented cognitive deficits after TBI associated with microglial reactivity. |
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ISSN: | 0889-1591 1090-2139 |
DOI: | 10.1016/j.bbi.2016.01.009 |