Development of 3D Microvascular Networks Within Gelatin Hydrogels Using Thermoresponsive Sacrificial Microfibers

Development of 3D Microvascular Networks Within Gelatin Hydrogels Using Thermoresponsive Sacrificial Microfibers

A 3D microvascularized gelatin hydrogel is produced using thermoresponsive sacrificial poly(N‐isopropylacrylamide) microfibers. The capillary‐like microvascular network allows constant perfusion of media throughout the thick hydrogel, and significantly improves the viability of human neonatal dermal...

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Veröffentlicht in:Advanced healthcare materials 2016-04, Vol.5 (7), p.781-785
Hauptverfasser: Lee, Jung Bok, Wang, Xintong, Faley, Shannon, Baer, Bradly, Balikov, Daniel A., Sung, Hak-Joon, Bellan, Leon M.
Format: Artikel
Sprache:eng
Schlagworte:
Acrylic Resins - pharmacology
artificial vasculature
Constants
Dermis - cytology
Encapsulation
Fibroblasts
Fibroblasts - cytology
Fibroblasts - drug effects
Gelatin - pharmacology
gelatin hydrogel
Gelatins
Humans
Hydrogels
Hydrogels - pharmacology
Imaging, Three-Dimensional
Infant, Newborn
Microfibers
Microscopy, Confocal
Microvessels - drug effects
Networks
Perfusion
poly(N-isopropylacrylamide)
Temperature
Three dimensional
tissue engineering
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Zusammenfassung:A 3D microvascularized gelatin hydrogel is produced using thermoresponsive sacrificial poly(N‐isopropylacrylamide) microfibers. The capillary‐like microvascular network allows constant perfusion of media throughout the thick hydrogel, and significantly improves the viability of human neonatal dermal fibroblasts encapsulated within the gel at a high density.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.201500792